TABLE 4

OSA on chromosomes 3,4, and 14

PhenotypeLinked subset*Position (cM)Nearest markerInitial LODMax LODSubsetting variable trait
Empirical P valuePercentage of linked families
Optimal subsetRemaining families
Chromosome 3p
    CCPHDL cholesterol (S)85AGAT1281.375.1936.5 ± 7.046.3 ± 13.30.04631
Non-HDL cholesterol (S)85AGAT1281.325.39127.8 ± 24.8151 ± 43.20.04028
    CVD2HDL cholesterol (S)87AGAT1282.197.0437.5 ± 7.145.2 ± 13.40.00625*
Chromosome 3q
    CarCPC-reactive protein (H)130D3S24601.313.161.28 ± 1.470.32 ± 0.480.05835
    CCPHDL cholesterol (L)132D3S24601.303.8734.0 ± 7.147.4 ± 12.30.04434
    CVD1LDL cholesterol (S)124D3S45231.014.0499.5 ± 21.9109 ± 35.10.04130*
A1C (H)129D3S45231.363.418.03 ± 1.946.44 ± 1.110.01566*
A1C (S)134D3S17641.364.267.73 ± 1.606.93 ± 1.910.02658*
    CVD2A1C (H)133D3S17642.604.917.76 ± 1.876.27 ± 1.040.01780*
A1C (S)134D3S17642.575.577.69 ± 1.596.94 ± 1.940.05060*
    Metabolic syndromeHDL cholesterol (L)148D3S17641.825.0334.5 ± 7.2847.6 ± 12.40.003636*
HDL cholesterol (S)148D3S17641.835.2034.8 ± 7.147.4 ± 12.60.02535*
Chromosome 4
    CarCPNon-HDL cholesterol (H)144D4S16441.173.21171 ± 41.6128 ± 29.60.02641
    CCPWaist circumference (H)146D4S16252.053.86119 ± 19.299.2 ± 12.60.04137
A1C (H)147D4S16252.023.437.9 ± 1.96.3 ± 1.00.0572
    CVD1Triglycerides (H)146D4S16251.102.77272 ± 161145 ± 620.035349*
    CVD2HDL cholesterol (L)144D4S16252.314.0237.8 ± 8.551.0 ± 13.40.021462*
    Metabolic syndromeA1C (H)146D4S16251.764.357.89 ± 1.906.36 ± 1.080.00473*
A1C (S)146D4S16251.764.357.89 ± 1.906.36 ± 1.080.027773*
Non-HDL cholesterol (H)146D4S16251.893.63176 ± 44132 ± 310.03231*
    Type 2 diabetesWaist circumference (H)146D4S16252.474.31117 ± 18.998.6 ± 12.50.0345
Chromosome 14
    CarCPTriglycerides (H)25ATA77F051.394.74288 ± 170151 ± 63.90.000642
Triglycerides (S)32ATA29G03Z0.934.97273 ± 141165 ± 1130.01339
    CCPTriglycerides (H)21D14S7420.502.77283 ± 167148 ± 61.00.03644
    CVD1A1C (H)17D14S7420.943.778.55 ± 2.136.66 ± 1.140.01043*
    CVD2Triglycerides (H)22ATA77F051.994.90283 ± 167150 ± 64.40.003944*
Triglycerides (S)22ATA77F051.994.90282 ± 167150 ± 640.03044*
Waist circumference (cm) (S)23ATA77F052.246.06104 ± 11.4106 ± 19.40.00827*
Non-HDL cholesterol (H)23ATA77F052.103.53173 ± 43.1130 ± 30.10.04437*
    Metabolic syndromeTriglycerides (H)24ATA77F052.254.22286 ± 169151 ± 650.01442*
C-reactive protein (L)23ATA77F052.334.160.37 ± 0.371.53 ± 1.770.01978*
C-reactive protein (S)26D14S6081.824.750.54 ± 0.450.68 ± 1.240.04935*
    Type 2 diabetesTriglycerides (H)38ATA29G03Z0.723.46285 ± 169151 ± 65.50.02243
  • Traits with P < 0.05 and included ≥25% families.

  • *

    * Subset code: H, high; L, low; S, optimal slice.