TABLE 2

Effects of leptin treatment on LIRKO mice

LOXLOX + leptinLIRKOLIRKO + leptin
Change in weight (g)0.8 ± 0.2−0.2 ± 0.2*1.4 ± 0.30.3 ± 0.3
Food intake (g · day−1 · mouse−1)3.5 ± 0.12.4 ± 0.1*4.0 ± 0.32.3 ± 0.1
Blood glucose (mg/dl)146 ± 7128 ± 8179 ± 17125 ± 10
Insulin (ng/ml)0.30 ± 0.060.17 ± 0.174.3 ± 0.852.0 ± 0.44
Leptin (ng/ml)6.6 ± 0.959 ± 12*34 ± 7.7229 ± 21
  • Data are means ± SE (n = 4–8). LOX and LIRKO mice were treated with vehicle or leptin (30 μg/day) for 4 days. The change in weight and food intake were measured over the 4 days. Blood glucose, insulin, and leptin were measured in the nonfasted state at the end of the experiment, just prior to killing.

  • *

    * P < 0.05, leptin treatment of LOX;

  • P < 0.05, leptin treatment of LIRKO;

  • P < 0.05, LOX vs. LIRKO (untreated).