TABLE 1

Subsets of thymocytes by genotype

Genotype/subsetCD4 CD8 (%)CD4+ CD8+ (%)CD4+ CD8 (%)CD4 CD8+ (%)
NOD4.8 ± 2.582 ± 3.512 ± 2.53.8 ± 0.9
TCR+ RAG+3.6 ± 2.066 ± 4.217 ± 2.96.0 ± 1.2
TCR+ RAG3.6 ± 1.193 ± 1.4*3 ± 0.5*1 ± 0.0
TCR+ RAG Ins27.5 ± 4.388 ± 6.22.7 ± 1.31.4 ± 1.2
  • Data are means ± SE measured as percentages of gated cells. Thymic subsets vary according to genotype of transgenic mice. Significantly more double-positive thymocytes exist in TCR+ RAG−/− than in TCR+ RAG+ (P < 0.001) mice. The TCR+ RAG−/− mice show significantly fewer single positive CD4+ T-cells compared with the TCR+ RAG+ mice (P < 0.001).

  • *

    * Statistically significant differences.