TABLE 1

Body weights and blood glucose levels of the mice

Nondiabetic wild-typeDiabetic wild-typeNondiabetic RAGE−/−Diabetic RAGE−/−
Body weight (g)23.7 ± 3.218.9 ± 4.3*22.5 ± 2.919.0 ± 2.2*
Blood glucose (mg/dl)161.1 ± 37.8463.1 ± 65.3*139.9 ± 42.8457.5 ± 81.0*
Glucose-derived AGEs (units/ml)1.11 ± 0.592.68 ± 0.38*0.70 ± 0.382.20 ± 1.09*
CML (units/ml)0.20 ± 0.140.56 ± 0.320.25 ± 0.100.42 ± 0.30
  • Data are means ± SD. Body weight and postprandial blood glucose were measured just before the implantation of the matrigel. Glucose-derived AGEs and CML were measured when the mice were killed.

  • *

    * P < 0.05 vs. control, Student’s t test.