TABLE 3

Incidence rates of type 2 diabetes per 1,000 person-years by tertiles of systemic immune mediator concentrations

Tertile 1 (low)Tertile 2 (intermediate)Tertile 3 (high)P (trend)Padj. (trend)
RANTES
    Intervention21.939.364.0*0.0080.048
    Control74.247.398.90.2541.000
MIF
    Intervention53.443.722.20.0390.195
    Control80.374.362.50.3411.000
IL-6
    Intervention36.840.341.20.7951.000
    Control75.571.968.90.2691.000
CRP
    Intervention29.842.842.90.7791.000
    Control45.592.8*82.20.1140.684
SAA
    Intervention38.846.830.40.2440.976
    Control61.975.980.30.4371.000
sICAM-1
    Intervention43.042.031.10.3961.000
    Control83.366.965.40.3161.000
  • Tertiles of intervention group or control group contain ∼85 subjects. P values for the linear trend were adjusted for sex, age, and BMI at baseline.

  • *

    * P < 0.05;

  • P < 0.10 in comparison to tertile 1 taking into account two tests within a treatment group. Padj., P value for the linear trend adjusted for 6 multiple tests within a treatment group, using Holm’s step-down Bonferroni procedure.