TABLE 1

Contractile parameters, MVo2, and cardiac efficiency in Langendorff-perfused wild-type and db/db mouse hearts

Glucose
Glucose + palmitate
Wild typedb/dbWild typedb/db
n131366
Wet heart wt (g)0.14 ± 0.010.13 ± 0.0030.12 ± 0.0030.12 ± 0.04
Heart rate (bpm)362.3 ± 3.6358.4 ± 5.3364 ± 0.9355.5 ± 7.6
End diastolic pressure (mmHg)10.9 ± 0.912.5 ± 112.9 ± 2.813.4 ± 1.9
End systolic pressure (mmHg)69.9 ± 2.160 ± 3.8*57.2 ± 3.144.9 ± 3.7*
Developed pressure (mmHg)58.9 ± 2.247.5 ± 3.3*44.3 ± 4.831.4 ± 3.9*
RPP21.4 ± 0.917 ± 1.2*16.1 ± 1.711.2 ± 1.4*
dP/dt min (mmHg/s)2,408.5 ± 115.32,124.4 ± 155.92,133.7 ± 64.21,846.3 ± 97.8
dP/dt max (mmHg/s)2,830.2 ± 118.82,608.5 ± 174.42,695 ± 98.32,299.8 ± 132.8
Coronary flow (ml/min)1.3 ± 0.071.4 ± 0.111.8 ± 0.151.5 ± 0.14
MVo2 (μmol · min−1 · g−1)23.6 ± 1.523.9 ± 1.817.3 ± 1.625 ± 2.8*
Cardiac efficiency (%)28 ± 1.922.8 ± 2.728.6 ± 3.314.1 ± 2.3§
  • Data are means ± SE.

  • *

    * P < 0.05,

  • §

    § P < 0.005 vs. wild type under the same perfusion conditions;

  • P < 0.05,

  • P < 0.005 vs. glucose.

  • P < 0.05 vs. wild type under the same perfusion condition with Mann-Whitney test.