TABLE 1

Metabolic parameters of wild-type and Cideb-null mice

ParameterNormal diet
P value*High-fat diet
P value*
Wild typenCideb nullnWild typenCideb nulln
TAG (mmol/l) (fed)0.55 ± 0.0480.40 ± 0.0370.210.82 ± 0.1580.48 ± 0.0680.0307
NEFA (mEq/l) (fed)1.02 ± 0.1580.60 ± 0.0970.030.97 ± 0.0680.74 ± 0.1180.09
Ketone body (mmol/l) (fed)0.10 ± 0.0180.10 ± 0.0270.960.17 ± 0.0580.18 ± 0.0380.80
Leptin (ng/ml) (fed)3.50 ± 0.2180.60 ± 0.1470.0147.76 ± 0.8882.80 ± 0.5480.0003
Glucose (mmol/l) (fed)9.41 ± 0.46167.56 ± 0.20150.0011§11.04 ± 0.63168.72 ± 0.29160.0018§
Glucose (mmol/l) (fasted)7.33 ± 0.26166.78 ± 0.25150.158.28 ± 0.27167.39 ± 0.34160.08
Adiponectin (μg/ml) (fed)9.94 ± 0.64811.72 ± 0.5170.066.62 ± 0.6188.53 ± 0.5480.0466
Resistin (ng/ml) (fed)5.92 ± 0.7486.17 ± 0.6670.819.80 ± 1.8788.59 ± 0.9280.58
Body wt (g)36.79 ± 1.58833.45 ± 0.5470.0843.83 ± 1.19837.05 ± 1.3280.0019§
Food intake (g/day)4.41 ± 0.04685.00 ± 0.06680.0206NDND
Liver (g)1.62 ± 0.0981.51 ± 0.0470.301.85 ± 0.0881.66 ± 0.0580.05
Kidney (g)0.42 ± 0.0280.43 ± 0.0270.600.45 ± 0.0180.47 ± 0.0280.24
Spleen (g)0.10 ± 0.00380.07 ± 0.00370.00020.113 ± 0.00880.108 ± 0.00880.64
Heart (g)0.17 ± 0.00280.16 ± 0.00770.120.17 ± 0.005780.17 ± 0.00580.38
Inguinal fat (g)0.77 ± 0.1480.39 ± 0.0270.032.13 ± 0.1181.08 ± 0.178<0.0001
Gonadal fat (g)1.06 ± 0.1980.46 ± 0.0370.0132.47 ± 0.1681.23 ± 0.178<0.0001
Retroperitoneal fat (g)0.57 ± 0.1180.15 ± 0.0170.0037§1.12 ± 0.1380.47 ± 0.078<0.0001
Mesenteric fat (g)0.65 ± 0.1280.27 ± 0.0370.01241.15 ± 0.0680.45 ± 0.058<0.0001
Subcutaneous fat (g)0.47 ± 0.0980.22 ± 0.0270.02751.48 ± 0.1280.61 ± 0.088<0.0001
  • *

    * P values are the results of nonpaired Student's t test.

  • P < 0.05.

  • P < 0.001.

  • §

    § P < 0.01. ND, not determined.