TABLE 1

Responses from clusters identified by SPM

Aware
Unaware
Aware
Unaware
5 mmol/l2.6 mmol/l5 mmol/l2.6 mmol/lHypoglycemic-euglycemicHypoglycemic-euglycemic
Left ventral striatum*85.22 ± 1.5793.61 ± 1.1585.63 ± 4.5290.28 ± 4.208.39 ± 1.574.65 ± 2.18
Right ventral striatum84.90 ± 3.3792.98 ± 3.0586.16 ± 4.9991.90 ± 4.638.09 ± 1.035.73 ± 3.39
Occipital cortex*96.28 ± 6.61107.37 ± 9.1793.76 ± 4.4698.21 ± 3.7711.09 ± 3.784.45 ± 2.66
Left cerebellum63.36 ± 3.9557.92 ± 9.8963.92 ± 4.4360.59 ± 5.67−5.44 ± 10.53−3.33 ± 8.29
Right cerebellum*71.10 ± 3.8377.77 ± 5.3071.03 ± 4.5567.63 ± 5.206.67 ± 4.70−3.39 ± 3.37
Brainstem*45.20 ± 4.2845.75 ± 3.6049.27 ± 3.0342.78 ± 3.790.55 ± 2.34−6.48 ± 2.38
Right orbitofrontal cortex*82.38 ± 8.6074.25 ± 10.9980.84 ± 4.4182.47 ± 3.30−8.13 ± 3.561.64 ± 3.17
Left amygdala*60.55 ± 2.2163.11 ± 2.4861.26 ± 3.3357.41 ± 3.182.56 ± 1.28−3.85 ± 2.35
Left white matter45.80 ± 4.6639.01 ± 3.8746.54 ± 1.8238.79 ± 1.49−6.79 ± 1.33−7.75 ± 2.12
Right white matter42.75 ± 3.1636.09 ± 3.5844.20 ± 2.4536.10 ± 2.70−6.65 ± 1.30−8.10 ± 1.89
Hypothalamus, parahippocampal gyrus34.90 ± 1.1528.91 ± 2.1337.62 ± 2.2529.09 ± 1.52−5.93 ± 2.09−8.53 ± 1.39
  • Data are means ± SD of tracer uptake expressed as percent of a global mean (50) at different blood glucose levels (5 and 2.6 mmol/l) and of change between hypoglycemic and euglycemic conditions. Significant difference of the effect of condition (hypoglycemia) between the two groups (aware and unaware subjects),

  • * P < 0.01;

  • P < 0.05.