TABLE 1

Genetic factors for type 2 diabetes

GenedbGeneDescriptionStudies*GWA studies
CAPN1011132Calpain 10(ref. 20)
ENPP15167Pyrophosphatase/phosphodiesterase 1(ref. 21)
PPARG5468Peroxisome proliferator–activated receptor-γ(refs. 2225)(refs. 2, 4)
KCNJ113767Potassium inwardly rectifying channel, subfamily J, member 11(refs. 24, 26, 27)(refs. 2, 4)
HNF4A3172Hepatocyte nuclear factor-4α(refs. 28, 29)
TCF7L26934Transcription factor 7-like 2(refs. 3033)(refs. 26, 8, 9)
ARHGEF119826Rho guanine nucleotide exchange factor (GEF)-11(ref. 34)
SLC30A8169026Solute carrier family 30 (zinc transporter), member 8(refs. 48)
HHEX/IDE3087/3416Linkage disequilibrium block containing hematopoietically expressed homeobox and insulin-degrading enzyme genes(refs. 2, 48)
EXT2/ALX42132/60529Linkage disequilibrium block containing exostoses and arista-like homeobox-4 genes(ref. 5)
CDKAL154901CDK5 regulatory subunit–associated protein 1-like 1(2; 4; 68)
CDKN2A/B1029Linkage disequilibrium block located near cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) and 2B (p15) genes. Region also associated with myocardial infarction.(refs. 2, 4, 6, 7)
IGF2BP210644Insulin-like growth factor-2 mRNA binding protein-2(refs. 2, 4, 6, 7)
  • *

    * Including linkage, fine-mapping, and candidate gene studies.