TABLE 3

SNPs with evidence for replicated association with type 2 diabetes (combined P value <0.05) in Amish, Framingham, and Starr County studies

SNPChr.MbAllelePresent study
Amish
Framingham
StarrCounty
Combined
OR*POR*PHRRP§OR*PP
rs1775368172.70T/A5.156.7 × 10−50.840.93561.200.18042.850.00780.0392
rs18860041165.06A/G8.8 × 10−42.160.01581.190.26441.220.40430.0468
rs10496191273.59G/A1.885.5 × 10−31.130.14841.440.03291.340.17060.0277
rs10496193273.69C/T1.905.3 × 10−31.140.14571.390.04611.440.12310.0275
rs104976812189.38A/G12.976.8 × 10−50.650.99600.990.52604.390.00220.0358
rs2366760321.15A/G1.822.3 × 10−31.070.26301.000.50202.050.00610.0271
rs10517403437.05G/A1.575.0 × 10−31.330.00791.130.21041.360.19310.0132
rs1072389475.36T/C2.022.9 × 10−31.170.06900.990.52381.660.0350.0378
rs4606104103.51A/G2.023.7 × 10−41.220.03371.390.03141.150.33380.0143
rs5438625177.97T/C1.743.2 × 10−31.150.10881.270.07231.450.10840.0282
rs10488205711.92C/T2.202.3 × 10−3NANANANA1.960.03780.0378
rs1486171745.98A/T1.805.5 × 10−31.180.06331.000.50671.690.03540.0349
rs38471097130.56A/G1.882.2 × 10−3NANA1.910.01461.350.23210.0227
rs37808259132.19A/G4.923.3 × 10−30.990.51102.190.00071.080.50000.0084
rs21301541186.50C/T2.342.1 × 10−3NANA1.380.03201.480.10780.0230
rs20489731186.52T/G2.113.8 × 10−31.190.05071.590.00121.320.17390.0008
rs5864211194.50C/T1.654.0 × 10−31.280.01361.000.49071.390.13210.0290
rs178936911109.50T/C1.914.6 × 10−30.940.70151.010.48742.510.00290.0312
rs51641511121.56A/G2.635.0 × 10−51.260.01790.900.76681.820.02050.0120
rs73014341291.36C/A3.391.5 × 10−30.940.62631.350.15726.170.00140.0068
rs549391354.45C/A1.643.2 × 10−31.210.03600.870.74971.690.04850.0388
rs15377791381.92C/T1.732.2 × 10−30.940.71601.500.00191.530.07280.0053
rs92853251381.95C/G1.743.1 × 10−30.980.58801.400.01011.420.12310.0251
rs19592251440.11A/T1.951.2 × 10−30.980.58851.410.02381.850.01970.0118
rs104985471480.19C/A2.576.6 × 10−41.170.09011.070.35911.860.02790.0294
rs958435206.52G/C2.765.7 × 10−31.280.03411.440.02080.790.75980.0198
rs6140410207.69A/G2.986.0 × 10−30.890.83192.330.00151.050.46630.0211
rs12232712013.24G/A2.215.3 × 10−31.600.00391.200.22210.490.95460.0273
rs4771842013.25A/G2.321.2 × 10−31.000.50921.550.00451.000.50000.0351
rs60304472040.79C/T2.533.6 × 10−31.160.08210.910.72312.000.01440.0282
  • *

    * OR per copy of the allele listed first (which gave OR >1 in the present study); in the present study, this result is for the within-family analysis.

  • One-sided P for association in the direction observed in the present study.

  • HRR per copy of the allele listed first.

  • §

    § P from the generalized estimating equation analysis in the Framingham Heart Study (ref. 36).

  • P combined from all three populations (except the present study) by Fisher's method. Chr., chromosome; NA, not analyzed.