TABLE 2

Fifty SNPs most highly associated with type 2 diabetes from Amish GWAS

SNPChromo-somePosition*GeneAlleles 1/2StrandCase subjects (n)Control subjects (n)Allele 2 case subjectsAllele 2 control subjectsType 2 diabetes POR§Type 2 diabetes P (BMI)
rs2237457750693638Grb10A/G1242930.530.681.07 × 10−50.611.46 × 10−5
rs980720482272087PRKG2A/G1222870.800.901.25 × 10−50.524.87 × 10−5
rs105091991065295820G/T1242950.310.461.68 × 10−50.624.46 × 10−5
rs13731471720147237SPECC1A/T1242930.470.602.79 × 10−50.635.26 × 10−6
rs40825161071374662COL13A1C/G1222930.770.883.19 × 10−50.531.27 × 10−5
rs105091951065193372A/C1182810.420.283.30 × 10−51.627.1 × 10−5
rs13959312123535443A/G+1242930.680.586.36 × 10−51.572.90 × 10−5
rs3136279247871272MSH6G/T1242940.200.116.81 × 10−51.809.2 × 10−5
rs14467322134374210G/T1212950.510.377.38 × 10−51.550.0001
rs10485249670161908C/G+1242950.820.927.96 × 10−50.540.0004
rs27038131720055907SPECC1A/G1232850.510.648.12 × 10−50.642.36 × 10−5
rs19164121065340801C/T1242930.620.498.35 × 10−51.540.0002
rs19164111065340839C/G1232920.380.518.48 × 10−50.650.0002
rs37517971685124993MTHFSDA/T1232850.760.648.74 × 10−51.600.0005
rs9306212134418548C/T+1222900.540.418.74 × 10−51.550.0001
rs105092011065342248A/G1232930.620.498.80 × 10−51.530.0002
rs21584731720079682SPECC1C/T+1192920.510.390.00011.543.00 × 10−5
rs2502497675399083G/T+1162790.050.100.00010.430.0002
rs4301235106109632A/G1142720.160.270.00020.610.0002
rs10504553875038957TCEB1A/G1152750.770.890.00020.560.0003
rs92874282133912538FLJ34870C/T+1242870.830.710.00021.620.0002
rs105076011355047379A/G+1232940.040.120.00020.440.0006
rs994952678319674A/G+1202870.520.420.00021.520.0002
rs76045492133923233FLJ34870A/G1232940.260.400.00020.650.0002
rs27372458116727757TRPS1A/C1132760.580.710.00020.670.0003
rs15132873114754898SIDT1A/G+1202890.580.440.00021.490.0003
rs78177808119486147SAMD12C/T1202940.910.800.00021.850.0002
rs297765204435111A/G+1242950.750.630.00021.550.0004
rs44104423112434500A/G1232940.480.340.00021.520.0008
rs13519162139479918A/T1222880.370.560.00020.670.0006
rs15076662123532455A/T1192850.440.560.00020.660.0002
rs10498934683516566C/T1242930.570.690.00020.660.0004
rs7217293174671967A/G1192850.430.560.00020.650.0002
rs14929083159869201GFM1A/G+1222910.200.290.00020.620.0004
rs10484725678325880A/G+1242940.190.110.00021.750.0002
rs104874407125763796G/T1212840.170.230.00020.590.0002
rs10498881672999327RIMS1C/G1212890.880.950.00020.480.0019
rs93178211369008405C/T1232900.520.640.00020.670.0008
rs104874427125850492A/G+1242950.830.760.00031.680.0003
rs7233975107375942FBXL17C/T+1232950.240.360.00030.650.0014
rs68971505165833376A/G1232940.260.140.00031.600.0003
rs1458405678321198G/T1122700.510.400.00031.540.0002
rs105212051712809867KIAA0672A/G1222920.160.260.00030.600.0007
rs10237383174685924C/T1232940.440.550.00030.670.0002
rs13673133159848232GFM1C/T1242950.790.710.00031.570.0005
rs105212041712809385KIAA0672A/C+1242930.830.740.00031.650.0007
rs20345314137364060A/G1232890.800.880.00030.590.0006
rs12820903112779804CD96A/G+1242950.820.680.00041.580.0011
rs932809962382544A/G1222940.740.840.00040.630.0004
rs104975672181111709KIAA1604A/G+1242950.930.850.00041.980.0005
  • *

    * Genome build 36.1.

  • Genic region that contains associated SNPs.

  • P values derived using variance components analysis under an additive genetic model, adjusted for age, sex, and family structure.

  • §

    § OR calculated from a liability threshold model in SOLAR and estimated as allele 2 versus allele 1.

  • P values derived using variance components analysis under an additive genetic model, adjusted for age, sex, BMI, and family structure. Our complete dataset with results from all models are available online (available at http://www.medschool.umaryland.edu/amishstudies/index.asp).