TABLE 4

SNPs associated with type 2 diabetes in the Amish (P < 0.005) and providing evidence for either internal consistency (association with an OGTT-derived quantitative trait in the Amish) or external replication (associated with type 2 diabetes in an independent population)

SNPChromo-somePosition*GeneStrandAssociated with type 2 diabetes in Amish (P < 0.005)
Internal consistency with OGTT-derived quantitative traits in Amish (P < 0.005)
External replication with type 2 diabetes in independent populations (P < 0.005)
Allele 1/2Allele 2 case subjectsAllele 2 control subjectsPORTraitPPopulationP§OR
rs6891571183074135C1orf24+A/T0.690.800.0010.67Pima Indians0.0020.65
rs28187811215203396ESRRG+C/T0.890.810.0031.61GAUC0.002
rs13437471240794106+A/C0.300.210.0021.43HOMA-IR0.002
IAUC0.002
rs10490049240426854SLC8A1A/C0.230.140.0021.54Fasting glucose0.001
GAUC0.001
rs3845971359975712FHIT+C/T0.790.680.0041.42GAUC4.0 × 10−4Mexican Americans0.0041.46
rs9312113463643792+C/G0.750.640.0041.41FHS0.013, 0.0031.66
rs3775745471147663CSN3A/C0.260.390.0020.70Mexican Americans0.0030.68
rs14229305167330171ODZ2+C/T0.040.110.0030.52HOMA-IR0.002
rs93217436140005650A/C0.420.320.0031.42FHS0.002, 0.0241.60
rs10487563748905713C/T0.150.270.0020.68ISI0.001
rs2237457750693638Grb10A/G0.530.681.1 × 10−50.61GAUC0.001
rs104882847119742580KCND2A/G0.120.170.0010.60HOMA-IR0.003
rs10504133853152586+C/T0.430.540.0020.72IAUC0.001
rs105052298115908561+C/T0.270.150.0021.50GAUC0.004
rs28044981033660713NRP1A/G0.490.360.0011.42Fasting glucose0.003
rs7686761044022687+A/T0.850.910.0020.61Fasting glucose0.004
rs24378711090268360C10orf59+A/C0.470.570.0030.72ISI0.001
rs22895221239616798CNTN1+C/T0.640.520.0011.46Fasting glucose0.004
rs79860101391517260GPC5+A/G0.440.340.0021.41FHS0.004, 0.0421.59
rs29532711847696031A/T0.270.430.0020.69GAUC0.004
rs297765204435111+A/G0.750.632.1 × 10−41.55Fasting glucose0.004
  • *

    * Genome build 36.1.

  • Genic region that contains associated SNPs.

  • OR calculated from a liability threshold model in SOLAR and estimated as allele 2 versus allele 1.

  • §

    § Case-control general estimating equation and family-based association test P values given for Framingham Heart Study (FHS) data; summary P value given for Pima Indians. All insulin traits (HOMA-IR, IAUC, and ISI) were natural log transformed prior to analysis.