TABLE 3

Mean diabetes-related quantitative trait levels by genotype for eleven 100K SNPs with significant associations in the FHS family sample that replicated the same quantitative trait in the nonoverlapping FHS unrelated sample

SNPFHS 100K family sample
FHS unrelated replication sample
Subjects with diabetes (%)
Mean trait values
Subjects with diabetes (%)
Mean trait values
1/2111222Trait111222111222111222
rs625643A/G77.98.9Fasting insulin (μU/ml)30.628.131.48.68.612.727.130.531.5
HOMA-IR7.46.878.387.17.938.36
rs952635A/G10.97.91FPG (mg/dl)100999311.610.110.210310198
HOMA-IR8.47.46.78.387.7
rs7531174C/T13.312.76A1C (%)5.755.45.1817.710.910.45.825.565.48
rs2715755C/T7.67.110.3ISI_0–12027.226.125.710.511.210.526.225.524.9
rs729511A/G6.97.511.4Fasting insulin (μU/ml)27.530.8319.610.911.528.83131.7
HOMA-IR7.027.878.157.218.248.39
rs2545523A/T9.17.212.1HOMA-IR7.77.97.51012.711.888.18.9
rs1355037C/G9.49.97.6ISI_0–12026.325.926.312.310.710.822.625.125.8
rs1416406C/T7.58.69.4HOMA-IR7.18.19.79.113.110.67.88.57.9
rs10500679C/G6.310.56.8A1C (%)5.085.325.266.910.611.85.285.55.56
rs2241119C/T05.19.4HOMA-IR6.66.785.911.710.77.17.98.2
rs2009833A/G9.79.86.4FPG (mg/dl)1011009714.611.49.510810299
A1C (%)5.635.285.195.725.555.42
HOMA-IR8.67.97.39.188
mFPG (mg/dl)100989710410199
  • SNPs significantly associated with quantitative traits in the FHS family 100K sample were tested for replication in a nonoverlapping unrelated FHS sample. Mean measurements for each trait are presented by genotype, with alleles shown in alphabetical order as “1/2”.