TABLE 6

Association of confirmed SNPs from previous high-density GWA scans in FHS

ChrGeneOriginal SNP100K SNPr2FHS MAFAllelesHR (95% CI)Cox P valueFBAT P valueTraitGEE
FBAT
AllelePAlleleP
10TCF7L2rs7903146rs71009270.500.49A/G1.56 (1.1–2.1)0.0070.04FPGG0.08G0.60
mFPGG0.03G0.13
A1CG0.67A0.15
Fasting insulinA0.94A0.30
HOMA-IRG0.43A0.65
ISI_0–120A0.12A0.59
8SLC30A8rs13266634rs19952220.1970.44A/G0.96 (0.69–1.3)0.800.01FPGA0.43A0.006
mFPGA0.46A0.008
A1CA0.82A0.07
Fasting insulinG0.93G0.99
HOMA-IRA0.75A0.23
ISI_0–120A0.40G0.69
10HHEXrs7923837rs105096450.7020.33G/T1.04 (0.75–1.5)0.810.49FPGT0.83T0.35
rs1111875mFPGT0.67T0.43
A1CT0.07T0.27
Fasting insulinT0.13T0.87
HOMA-IRT0.19T0.65
ISI_0–120G0.48T0.99
11LOC387761rs7480010rs105012780.2840.11A/T0.75 (0.43–1.3)0.300.89FPGT0.83T0.28
mFPGA0.79T0.36
A1CA0.71A0.75
Fasting insulinT0.10T0.008
HOMA-IRT0.13T0.01
ISI_0–120A0.30A0.047
11EXT2rs1113132rs9628480.4740.33C/T1.16 (0.84–1.6)0.370.13FPGT0.002T0.002
rs11037909mFPGT0.04T0.007
rs3740878A1CT0.70T0.35
Fasting insulinT0.98C0.83
HOMA-IRT0.22T0.27
ISI_0–120C0.21C0.049
6CDKAL1rs7754840rs23285450.3470.13C/G0.98 (0.67–1.5)0.930.73FPGC0.90C0.29
mFPGG0.97C0.31
A1CG0.19G0.80
Fasting insulinC0.97C0.76
HOMA-IRC0.83C0.43
ISI_0–120C0.09C0.19
3IGF2BP2rs1470579rs105138000.3280.22A/C0.77 (0.55–1.1)0.120.71FPGA0.28A0.21
rs4402960mFPGA0.03A0.37
A1CA0.26A0.49
Fasting insulinC0.12C0.55
HOMA-IRC0.45C0.94
ISI_0–120A0.78C0.60
  • SNPs shown to be significantly associated with type 2 diabetes in recent high-density GWA scans (16–19) were examined for association with diabetes incidence or related quantitative traits within the FHS 100K dataset. A 100K SNP was found to be in moderate to low linkage disequilibrium with the previously associated SNP in each case. Nominally significant associations in a consistent direction were found in FHS for five of these SNPs (shown in boldface). Chr, chromosome.