TABLE 4

Distribution of IL6R polymorphisms in diabetic and control subjects

SNPsGene regionGenotypesFrequency
P valueFDR
Case subjectsControl subjects
SNP1Exon 1GG238 (36.6)347 (34.0)0.430.84
GA311 (47.8)493 (48.3)
AA102 (15.6)180 (17.7)
SNP2Intron 1TT414 (63.0)625 (60.3)0.420.84
TC215 (32.7)357 (34.4)
CC28 (4.3)55 (5.3)
SNP3Intron 1TT223 (33.9)353 (34.1)0.590.84
TA315 (47.9)513 (49.6)
AA119 (18.1)168 (16.3)
SNP4Intron 1CC241 (36.5)372 (36.0)0.550.84
CT327 (49.5)498 (48.2)
TT92 (14.0)164 (15.8)
SNP5Intron 1AA185 (28.6)323 (31.7)0.340.84
AC338 (52.3)521 (51.2)
CC123 (19.1)174 (17.1)
SNP6Intron 6TT231 (34.9)354 (34.3)0.970.97
TG330 (49.8)518 (50.2)
GG101 (15.3)160 (15.5)
SNP7Exon 9AA233 (35.7)372 (35.9)0.960.97
AC327 (50.1)510 (49.1)
CC93 (14.2)156 (15.0)
SNP8Intron 9TT471 (71.3)715 (68.8)0.160.84
TC178 (26.9)290 (27.9)
CC12 (1.8)34 (3.3)
SNP9Intron 9AA375 (56.8)614 (59.4)0.580.84
AG252 (38.2)372 (36.0)
GG33 (5.0)48 (4.6)
SNP10Exon 10GG426 (64.6)696 (66.5)0.880.97
(3′ untranslated region)GA213 (32.3)321 (30.7)
AA20 (3.1)29 (2.8)
  • Data are n (%), unless otherwise indicated. The missing genotyping is not counted.