Distribution of IL6R polymorphisms in diabetic and control subjects
| SNPs | Gene region | Genotypes | Frequency | P value | FDR | ||
|---|---|---|---|---|---|---|---|
| Case subjects | Control subjects | ||||||
| SNP1 | Exon 1 | GG | 238 (36.6) | 347 (34.0) | 0.43 | 0.84 | |
| GA | 311 (47.8) | 493 (48.3) | |||||
| AA | 102 (15.6) | 180 (17.7) | |||||
| SNP2 | Intron 1 | TT | 414 (63.0) | 625 (60.3) | 0.42 | 0.84 | |
| TC | 215 (32.7) | 357 (34.4) | |||||
| CC | 28 (4.3) | 55 (5.3) | |||||
| SNP3 | Intron 1 | TT | 223 (33.9) | 353 (34.1) | 0.59 | 0.84 | |
| TA | 315 (47.9) | 513 (49.6) | |||||
| AA | 119 (18.1) | 168 (16.3) | |||||
| SNP4 | Intron 1 | CC | 241 (36.5) | 372 (36.0) | 0.55 | 0.84 | |
| CT | 327 (49.5) | 498 (48.2) | |||||
| TT | 92 (14.0) | 164 (15.8) | |||||
| SNP5 | Intron 1 | AA | 185 (28.6) | 323 (31.7) | 0.34 | 0.84 | |
| AC | 338 (52.3) | 521 (51.2) | |||||
| CC | 123 (19.1) | 174 (17.1) | |||||
| SNP6 | Intron 6 | TT | 231 (34.9) | 354 (34.3) | 0.97 | 0.97 | |
| TG | 330 (49.8) | 518 (50.2) | |||||
| GG | 101 (15.3) | 160 (15.5) | |||||
| SNP7 | Exon 9 | AA | 233 (35.7) | 372 (35.9) | 0.96 | 0.97 | |
| AC | 327 (50.1) | 510 (49.1) | |||||
| CC | 93 (14.2) | 156 (15.0) | |||||
| SNP8 | Intron 9 | TT | 471 (71.3) | 715 (68.8) | 0.16 | 0.84 | |
| TC | 178 (26.9) | 290 (27.9) | |||||
| CC | 12 (1.8) | 34 (3.3) | |||||
| SNP9 | Intron 9 | AA | 375 (56.8) | 614 (59.4) | 0.58 | 0.84 | |
| AG | 252 (38.2) | 372 (36.0) | |||||
| GG | 33 (5.0) | 48 (4.6) | |||||
| SNP10 | Exon 10 | GG | 426 (64.6) | 696 (66.5) | 0.88 | 0.97 | |
| (3′ untranslated region) | GA | 213 (32.3) | 321 (30.7) | ||||
| AA | 20 (3.1) | 29 (2.8) | |||||
Data are n (%), unless otherwise indicated. The missing genotyping is not counted.