TABLE 1

Association between SNPs in TCF7L2 and type 2 diabetes in a Pima Indian population–based study

SNP (chr. position)Allele 1/2Freq. allele 2Diabetic subjects
Diabetic subjects
P value: general (upper row) and within family (lower row)
1/1 (%)1/2 (%)2/2 (%)1/1 (%)1/2 (%)2/2 (%)AdditiveDominantRecessiveAdditive*
1,394 (76.8)390 (21.5)32 (1.8)1,130 (77.4)309 (21.2)21 (1.4)0.710.300.940.97 (0.81–1.15)
(114601494)0.730.340.980.95 (0.72–1.27)
rs10509966A/G0.151,199 (70.0)477 (27.9)36 (2.1)1,011 (74.1)330 (24.2)24 (1.8)0.080.850.040.85 (0.71–1.02)
(114666170)0.510.940.460.90 (0.67–1.22)
rs3862012T/C0.26964 (53.2)704 (38.9)141 (7.7)815 (56.5)523 (36.3)102 (7)0.440.740.420.95 (0.83–1.09)
(114672543)0.850.710.640.98 (0.78–1.23)
rs11196152T/C0.26946 (53.4)690 (38.9)137 (7.7)804 (56.5)520 (36.5)99 (7.0)0.430.730.410.95 (0.82–1.09)
(114676795)0.820.860.690.97 (0.77–1.23)
rs10509967A/C0.26909 (52.6)690 (39.9)130 (7.5)775 (56.6)506 (37.0)88 (6.4)0.270.490.300.92 (0.80–1.06)
(114685922)0.810.770.630.97 (0.77–1.23)
rs3814570C/T0.26963 (53.6)704 (39.2)131 (7.3)814 (56.4)536 (37.1)94 (6.5)0.400.590.430.94 (0.82–1.08)
(114698500)0.720.720.520.96 (0.77–1.20)
rs2094405G/A0.171,244 (68.1)517 (28.3)65 (3.6)1,028 (70.1)397 (27.1)42 (2.9)0.070.110.150.87 (0.75–1.01)
(114705679)0.790.420.971.03 (0.82–1.31)
rs12573128A/G0.37730 (40.8)821 (45.9)237 (13.3)560 (39.1)692 (48.3)182 (12.7)0.820.860.661.02 (0.90–1.15)
(114720787)0.780.830.581.03 (0.83–1.29)
rs7895307A/G0.31889 (49.0)744 (41.0)180 (9.9)690 (47.7)634 (43.8)123 (8.5)0.740.820.771.02 (0.90–1.16)
(114733951)0.420.260.760.91 (0.73–1.14)
r̅s̅7̅9̅0̅1̅6̅9̅5̅T/C̅0.081,379 (84.9)232 (14.3)13 (0.8)1,098 (83.8)199 (15.2)13 (1.0)0.220.200.311.15 (0.92–1.44)
(114744078)0.310.580.331.20 (0.85–1.69)
r̅s̅7̅9̅0̅3̅1̅4̅6̅C/T̅0.081,415 (85.4)226 (13.6)16 (1.0)1,124 (86.2)169 (13.0)11 (0.8)0.760.660.831.04 (0.82–1.32)
(114748339)0.920.940.891.02 (0.68–1.54)
r̅s̅7̅8̅9̅5̅3̅4̅0̅G/A̅0.101,482 (83.3)280 (15.8)18 (1.1)1,164 (82.0)241 (17.0)15 (1.1)0.330.400.411.11 (0.90–1.36)
(114791515)0.490.670.541.12 (0.81–1.53)
r̅s̅1̅1̅1̅9̅6̅2̅0̅5̅G/C̅0.101,514 (83.6)279 (15.4)17 (0.9)1,212 (83.1)231 (15.8)15 (1.0)0.490.260.661.07 (0.87–1.32)
(114797037)0.760.700.821.05 (0.77–1.44)
r̅s̅1̅2̅2̅5̅5̅3̅7̅2̅G/T̅0.011,747 (98.6)26 (1.5)0 (0)1,407 (98.8)18 (1.3)0 (0)0.72NA0.720.87 (0.41–1.86)
(114798892)0.59NA0.590.70 (0.19–2.53)
rs7085532A/G0.171,250 (68.6)514 (28.2)57 (3.1)1,054 (72.4)365 (25.1)37 (2.5)0.160.450.170.89 (0.76–1.05)
(114849453)0.480.310.210.90 (0.68–1.20)
rs10787475C/T0.44553 (31.3)870 (49.2)346 (19.6)473 (33.3)681 (48.0)265 (18.7)0.140.180.250.91 (0.80–1.03)
(114882458)0.430.800.350.92 (0.73–1.14)
rs1225404C/T0.48499 (27.4)922 (50.6)402 (22.1)427 (29.2)752 (51.4)284 (19.4)0.030.0050.360.87 (0.78–0.98)
(114904655)0.220.070.800.88 (0.72–1.08)
Pro500ThrC/A0.021,677 (96.7)58 (3.3)0 (0)1,308 (94.7)70 (5.2)0 (0)0.19NA0.191.31 (0.87–1.96)
0.49NA0.491.27 (0.65–2.49)
rs911770T/A0.35753 (41.4)834 (45.9)231 (12.7)618 (42.4)657 (45.1)181 (12.4)0.920.990.891.01 (0.89–1.14)
(114975665)0.930.710.900.99 (0.81–1.21)
  • P values were calculated using a general analytical model(upper value) and a within-family analytical model(lower value). P values adjusted for age, sex, birth year, and family membership. Significant P values(P < 0.05) are indicated by boldface.

  • *

    * OR(95% CI) is given per copy of allele 2; underlined alleles were the diabetes risk alleles in previous studies(ref. 1).

  • Representative SNP selected from supplemental Fig. 1; underlined SNPs had the strongest associations in the Icelandic study.