TABLE 2

Association between SNPs in TCF7L2 and BMI in a Pima Indian population–based study

SNP1/1 [1/1–2/2]1/2 [1/1–1/2]2/2 [1/2–2/2]P value: general (upper row) and within family (lower row)
AdditiveDominantRecessive
rs477167*
    BMI (kg/m2)37.3 ± 8.5 (2,364)36.8 ± 8.4 (652)36.5 ± 8.3 (50)0.190.370.24
    Sibpair difference in BMI1.4 ± 7.7 (17)−0.2 ± 10.4 (546)1.9 ± 9.1 (54)0.940.550.83
rs10509966*
    BMI (kg/m2)37.3 ± 8.5 (2,064)36.8 ± 8.5 (747)37.7 ± 9.1 (58)0.620.520.44
    Sibpair difference in BMI1.7 ± 8.5 (24)−0.5 ± 10.9 (580)0.8 ± 9.6 (51)0.370.890.36
rs3862012*
    BMI (kg/m2)37.4 ± 8.6 (1,669)37.0 ± 8.2 (1,141)36.2 ± 8.8 (229)0.080.080.21
    Sibpair difference in BMI−1.7 ± 10.2 (69)0.4 ± 10.3 (661)1.3 ± 9.0 (255)0.940.150.51
rs11196152*
    BMI (kg/m2)37.4 ± 8.6 (1,641)37.0 ± 8.3 (1,123)36.5 ± 9.0 (222)0.120.150.23
    Sibpair difference in BMI−2.2 ± 10.0 (68)0.4 ± 10.3 (632)1.5 ± 9.2 (237)0.870.210.60
rs10509967*
    BMI (kg/m2)37.3 ± 8.6 (1,574)37.0 ± 8.3 (1,107)36.7 ± 9.0 (208)0.270.410.34
    Sibpair difference in BMI−2.1 ± 10.5 (63)0.5 ± 10.2 (623)1.0 ± 9.2 (233)0.940.640.86
rs3814570*
    BMI (kg/m2)37.4 ± 8.6 (1,664)37.0 ± 8.2 (1,154)36.7 ± 9.0 (214)0.270.320.38
    Sibpair difference in BMI−1.5 ± 10.2 (70)0.3 ± 9.9 (670)1.0 ± 9.3 (244)0.790.430.46
rs2094405*
    BMI (kg/m2)37.2 ± 8.3 (2,130)37.1 ± 8.9 (853)36.9 ± 8.1 (99)0.690.990.66
    Sibpair difference in BMI−2.7 ± 8.4 (38)−0.9 ± 11.2 (709)−2.4 ± 10.0 (98)0.150.500.19
rs12573128*
    BMI (kg/m2)37.2 ± 8.4 (1,209)37.2 ± 8.7 (1,419)36.7 ± 7.8 (385)0.790.520.95
    Sibpair difference in BMI−1.3 ± 10.7 (87)0.0 ± 10.7 (715)1.0 ± 10.1 (580)0.880.500.51
rs7895307*
    BMI (kg/m2)37.3 ± 8.7 (1,477)37.2 ± 8.5 (1,295)36.3 ± 7.5 (320)0.370.070.87
    Sibpair difference in BMI1.3 ± 9.3 (75)0.6 ± 10.6 (747)2.5 ± 9.5 (273)0.040.00060.5
r̅s̅7̅9̅0̅1̅6̅9̅5̅
    BMI (kg/m2)37.3 ± 8.5 (2,303)36.4 ± 8.0 (401)34.7 ± 7.4 (24)0.010.060.02
    Sibpair difference in BMI2.7 ± 7.2 (27)−0.4 ± 10.6 (310)3.6 ± 7.8 (17)0.390.050.62
r̅s̅7̅9̅0̅3̅1̅4̅6̅
    BMI (kg/m2)37.4 ± 8.6 (2,367)36.2 ± 8.1 (366)34.2 ± 6.8 (25)0.0010.010.004
    Sibpair difference in BMI4.9 ± 7.5 (16)0.7 ± 11.4 (278)5.7 ± 7.7 (20)0.350.030.56
r̅s̅7̅8̅9̅5̅3̅4̅0̅
    BMI (kg/m2)37.4 ± 8.6 (2,473)36.4 ± 8.1 (488)36.1 ± 7.8 (31)0.020.290.03
    Sibpair difference in BMI3.3 ± 9.9 (26)0.4 ± 10.7 (395)3.8 ± 7.8 (31)0.460.200.64
r̅s̅1̅1̅1̅9̅6̅2̅0̅5̅
    BMI (kg/m2)37.3 ± 8.5 (2,549)36.3 ± 8.1 (477)36 ± 7.6 (30)0.0090.250.01
    Sibpair difference in BMI4.2 ± 9.5 (22)0.7 ± 10.3 (396)3.8 ± 8.4 (25)0.280.190.38
r̅s̅1̅2̅2̅5̅5̅3̅7̅2̅
    BMI (kg/m2)37.3 ± 8.5 (2,949)32.8 ± 6.3 (41)NA (0)0.0007NA0.0007
    Sibpair difference in BMINA (0)9.5 ± 13.8 (35)NA (0)0.007NA0.007
rs7085532*
    BMI (kg/m2)37.3 ± 8.6 (2,148)36.7 ± 8.2 (862)37.3 ± 7.7 (89)0.220.460.10
    Sibpair difference in BMI−3.6 ± 8.5 (31)0.0 ± 10.6 (612)−0.7 ± 10.6 (85)0.970.160.54
rs10787475*
    BMI (kg/m2)37.4 ± 8.5 (944)37.1 ± 8.6 (1,456)36.9 ± 8.4 (583)0.040.20.06
    Sibpair difference in BMI1.4 ± 9.0 (95)0.4 ± 10.6 (547)−0.7 ± 11.3 (463)0.210.720.15
rs1225404*
    BMI (kg/m2)37.4 ± 8.5 (861)37.3 ± 8.2 (1,570)36.6 ± 9.1 (642)0.010.0080.19
    Sibpair difference in BMI−1.0 ± 9.6 (102)0.4 ± 10.6 (547)0.6 ± 10.5 (498)0.270.160.81
Pro500Thr
    BMI (kg/m2)37.18 ± 8.4 (2,782)37.32 ± 8.9 (123)NA (0)0.61NA0.61
    Sibpair difference in BMINA (0)1.4 ± 10.0 (97)NA (0)0.23NA0.23
rs911770*
    BMI (kg/m2)37.2 ± 8.2 (1,292)37.1 ± 8.6 (1,386)37.2 ± 8.9 (386)0.840.650.56
    Sibpair difference in BMI−1.8 ± 10.6 (78)−0.5 ± 10.5 (741)−1.0 ± 10.6 (348)0.580.250.93
  • Data are means ± SD (n) unless otherwise indicated. Alleles for each SNP are given in Table 1. For each SNP, the unadjusted mean BMI ± SD is given for subjects in each genotypic group (upper line). For within-family analyses (lower line) the mean± SD difference in BMI among genotypically discordant sib-pairs is given; the difference is computed as the BMI for the sib with the genotype listed first minus that for the sib with the genotype listed second. For rs12255372, for example, among 35 genotypically discordant sibling pairs, the BMI for the sib with the 11 (GG) genotype was on average 9.5 kg/m2 higher than the BMI for the sib with the 12 (GT) genotype. P values were calculated using a general analytical model (upper value) and a within-family analytical model (lower value). P values adjusted for age, sex, birth year, and family membership. Significant P values (P < 0.05) are indicated by boldface.

  • *

    * A representative SNP selected from online Fig. 1; underlined SNPs had the strongest associations with type 2 diabetes in the Icelandic study.