TABLE 2

Relationships between diabetes susceptibility alleles and measures of β-cell function (30-min insulin response and β-cell glucose sensitivity) and whole-body insulin sensitivity (M/I)

Genomic region/ variantGenotype 1/2Trait111222P
rs10757283C/T30-min ins resp25.7 (17.8–37.2)26.3 (18.6–38.9)26.3 (16.6–38.9)0.678
CDKN2BGlucose sens111 (78–156)114 (80–158)114 (76–160)0.336
M/I133 (93–186)127 (91–176)124 (86–170)0.077
rs10811661T/C30-min ins resp25.7 (17.4–37.8)28.2 (20.0–38.9)28.8 (15.8–38.9)0.216
CDKN2BGlucose sens115 (79–157)109 (78–164)120 (78–157)0.504
M/I130 (94–179)123 (89–173)146 (101–181)0.293
rs564398A/G30-min ins resp26.3 (17.4–38.9)26.9 (18.6–38.0)25.1 (17.0–36.3)0.367
CDKN2BGlucose sens113 (77–149)114 (79–169)107 (71–147)0.413
M/I123 (91–173)129 (92–176)134 (92–189)0.065
rs10946398A/C30-min ins resp28.2 (19.5–39.8)25.1 (17.4–36.3)24.5 (15.8–36.3)0.0002
CDKAL1Glucose sens119 (83–170)111 (77–155)102 (68–140)9.86 × 10−5
M/I126 (86–172)129 (95–180)117 (89–178)0.108
rs1111875G/A30-min ins resp25.1 (17.0–35.5)26.0 (18.2–39.8)29.5 (20.0–39.8)0.0002
HHEX/IDEGlucose sens107 (72–154)117 (81–156)120 (82–175)0.009
M/I127 (91–175)128 (91–176)132 (95–184)0.135
rs13266634C/T30-min ins resp25.7 (17.4–37.5)27.0 (19.5–38.9)25.7 (18.4–38.9)0.128
SLC30A8Glucose sens112 (76–155)114 (80–159)125 (92–186)0.072
M/I128 (92–179)126 (89–167)153 (96–196)0.330
rs4402960G/T30-min ins resp26.9 (17.8–38.0)25.1 (18.2–38.0)28.5 (20.8–39.1)0.540
IGF2BP2Glucose sens115 (80–162)111 (76–154)118 (80–158)0.067
M/I131 (92–177)126 (91–176)126 (87–160)0.204
rs9939609A/T30-min ins resp25.1 (18.0–37.2)26.6 (17.5–38.9)26.3 (19.1–38.0)0.690
FTOGlucose sens111 (72–147)113 (79–158)114 (81–159)0.312
M/I123 (89–167)127 (88–177)134 (100–182)0.023
BMI25.5 (23.4–28.4)25.1 (22.8–28.1)24.6 (22.4–27.4)0.022
WHR0.88 (0.80–0.94)0.86 (0.79–0.93)0.85 (0.78–0.92)0.009
Fat mass21.3 (14.2–27.9)19.7 (14.7–25.6)19.3 (14.4–24.6)0.035
Pro12Ala (rs1801282)Pro/Ala30-min ins resp22.4 (18.6–28.2)24.5 (16.6–34.7)26.9 (18.6–39.8)0.028
PPARGGlucose sens136 (80–164)107 (75–149)115 (79–160)0.612
M/I127 (93–176)125 (87–179)168 (134–210)0.212
  • Data are median (25th–75th quartile). P values for linear trend analysis adjusted for age, sex, and recruitment center. Fat mass is measured in kilograms. Risk allele/variants are in boldface. 30-min ins resp, 30-min insulin response (pmol/mmol); Glucose sens, β-cell glucose sensitivity (pmol · min−1 · m−2 · mmol/l−1); M/I, whole-body insulin sensitivity (μmol · min−1 · kgffm−1 · nmol/l−1). ffm, fat-free mass.