TABLE 1

Association studies of type 2 diabetes in 4,089 type 2 diabetic case and 5,043 glucose-tolerant control subjects

VariantRisk alleleNearest geneGenotype distribution
Risk-allele frequencies
Unadjusted*
Adjusted
Glucose tolerant n (%)Type 2 diabetes n (%)Glucose tolerant % (95% CI)Type 2 diabetes % (95% CI)Allele frequency model OR (95% CI)Additive model OR (95% CI)Dominant model OR (95% CI)Recessive model OR (95% CI)
rs1111875CHHEXTT862 (18)602 (16)58.560.21.07 (1.01–1.14)1.13 (1.03–1.23)1.28 (1.08–1.50)1.11 (0.98–1.26)
CT2,279 (47)1,864 (48)(57.4–59.5)(59.1–61.3)Pfreq = 0.03Padd = 0.008Pdom = 0.004Prec = 0.1
CC1,694 (35)1,389 (36)
rs10811661TCDKN2BCC135 (2.7)63 (1.6)83.186.41.26 (1.16–1.38)1.30 (1.16–1.47)1.35 (0.90–2.02)1.36 (1.19–1.55)
CT1,365 (28)933 (24)(82.3–83.8)(85.6–87.1)Pfreq = 4 × 10−8Padd = 1 × 10−5Pdom = 0.2Prec = 8 × 10−6
TT3,410 (70)2,884 (74)
rs4402960TIGF2BP2GG2,389 (49)1,769 (46)30.232.21.10 (1.03–1.18)1.10 (1.00–1.21)1.17 (1.04–1.32)1.02 (0.83–1.25)
GT2,018 (42)1,660 (43)(29.3–31.2)(31.1–33.2)Pfreq = 0.004Padd = 0.04Pdom = 0.01Prec = 0.9
TT455 (9.4)403 (11)
rs9300039CAA43 (0.9)37 (1)91.090.50.93 (0.84–1.03)0.89 (0.77–1.03)1.11 (0.60–2.07)0.87 (0.74–1.02)
AC777 (16)650 (17)(90.4–91.6)(89.8–91.2)Pfreq = 0.2Padd = 0.1Pdom = 0.7Prec = 0.08
CC4,030 (83)3,127 (82)
  • Data are n (%), risk-allele frequencies in % (95% CI), or OR (95% CI). Patients having type 2 diabetes were recruited at the Steno Diabetes Center (n = 2,111), from the population-based Inter99 cohort (7,8) (n = 352), and from the ADDITION Study (10) (n = 1,626). Glucose-tolerant subjects were recruited from population-based studies at the Steno Diabetes Center (n = 521) and the Inter99 cohort (n = 4,522).

  • *

    * Differences in allele frequencies (Pfreq) not adjusted for age, sex, and BMI were calculated using Fisher's exact test.

  • P values compare genotype distributions between type 2 diabetic case and glucose-tolerant control subjects applying an additive (Padd), dominant (Pdom), or recessive (Prec) logistic regression model, while adjusting for age, sex, and BMI. The risk alleles were determined as previously reported (16).