TABLE 3

Quantitative metabolic traits in a population-based sample of 377 young healthy subjects stratified according to genotype

rs1111875 (HHEX/KIF11/IDE)
rs4402960 (IGF2BP2)
rs10811661 (CDKN2A/B)
rs9300093
TTTCCCPaddPdomPrecGGGTTTPaddPdomPrecCCCTTTPaddPdomPrecAAACCCPaddPdomPrec
n (men/women)61 (29/32)117 (56/61)191 (97/94)182 (90/92)156 (77/79)27 (13/14)11 (5/6)92 (42/50)262 (132/130)3 (2/1)52 (26/26)304 (152/152)
Age (years)25.9 ± 3.325.0 ± 3.525.1 ± 3.724.9 ± 3.725.5 ± 3.425.5 ± 3.125.9 ± 3.124.6 ± 3.925.4 ± 3.424.0 ± 1.725.4 ± 3.625.2 ± 3.5
BMI (kg/m2)23.7 ± 4.523.4 ± 3.623.76 ± 3.470.510.423.5 ± 3.623.5 ± 3.824.0 ± 4.70.90.90.622.7 ± 3.223.6 ± 4.023.7 ± 3.70.80.4123.6 ± 5.023.3 ± 3.623.6 ± 3.70.610.6
Acute serum insulin response 0–8 min (pmol/l × min)2,290 (1,540–3,220)1,860 (1,220–2,590)1,930 (1,160–2,930)0.080.040.42,160 (1,320–3,050)1,710 (1,180–2,500)1,890 (1,060–2,950)0.020.0040.91,770 (1,140–2,470)2,160 (1,430–3,080)1,890 (1,170–2,790)0.020.80.0091,290 (1,090–1,720)2,000 (1,230–2,720)1,970 (1,230–2,890)0.40.40.5
ΔPlasma glucose 2 min post-tolbutamide (pmol/l)−0.44 (−0.67 to −0.22)−0.56 (−0.89 to −0.33)−0.56 (−0.89 to −0.33)0.0070.0050.09−0.56 (−0.78 to −0.33)−0.56 (−0.89 to −0.33)−0.44 (−1.00 to −0.33)10.80.5−0.33 (−0.67 to −0.28)−0.56 (−0.89 to −0.33)−0.56 (−0.89 to −0.33)0.90.71−0.78 (−0.83 to −0.67)−0.44 (−0.89 to −0.33)−0.56 (−0.78 to −0.33)0.90.61
ΔSerum insulin 2 min post-tolbutamide (pmol/l)219 (123–348)178 (98–319)182 (91–295)0.020.090.05198 (117–342)176 (76–285)126 (74–369)0.030.020.4150 (117–308)235 (126–351)177 (97–303)0.20.80.1167 (113–256)191 (110–303)192 (98–336)0.60.80.6
Insulin sensitivity index [10−5 × (min × pmol/l)−1]11.6 (8.5–19.9)13.6 (9.1–19.5)12.7 (9.1–20.0)0.40.40.613.2 (9.0–19.1)13.2 (9.1–20.9)10.0 (5.8–17.9)0.70.80.219.1 (12.8–22.0)11.8 (8.5–17.1)13.6 (8.9–20.1)0.20.50.0718.1 (11.2–20.7)11.7 (8.8–16.9)13.3 (8.9–20.1)0.0310.02
Birth weight (g)3,390 ± 5783,370 ± 5793,350 ± 5520.70.70.83,370 ± 6043,390 ± 5203,290 ± 5800.810.43,570 ± 5823,200 ± 5333,410 ± 5700.10.20.023,350 ± 4953,270 ± 6473,380 ± 5590.20.80.2
Disposition index2.45 (1.76–3.96)2.65 (1.65–3.72)2.65 (1.73–4.01)0.60.50.82.89 (1.80–4.12)2.45 (1.60–3.37)2.03 (0.99–3.83)0.0090.010.13.25 (2.52–4.01)2.59 (1.58–3.84)2.65 (1.63–4.00)0.40.40.51.61 (1.09–3.30)2.41 (1.44–3.40)2.72 (1.73–3.95)0.040.50.04
  • Data are median (interquantile range) or means ± SD (age, BMI, and birth weight). Values of serum insulin, insulin sensitivity index, and disposition index were transformed using cube root before statistical analysis. Calculated P values were adjusted for age, sex, and BMI (where appropriate) assuming an additive (Padd), dominant (Pdom), or recessive (Prec) model. Acute serum insulin response 0–8 min, Δplasma glucose 2 min post-tolbutamide, Δserum insulin 2 min post-tolbutamide (pmol/l), insulin sensitivity index, and the disposition index were calculated as described elsewhere (9).