TABLE 2

Genotype and allele frequencies of the SOD2 rs4880 polymorphism

rs4880Control subjects
Case subjects
OR (95% CI)P value
FinnishSwedishP value*Finnish + SwedishFinnishSwedishP value*Finnish + Swedish
GenotypeVal/Val25.4 (91)19.9 (39)23.5 (130)26.5 (212)28.7 (43)26.8 (255)1.15 (0.85–1.55)
Val/Ala51.1 (183)51.5 (101)51.3 (284)48.9 (392)43.3 (65)48.1 (457)0.94 (0.73–1.22)
Ala/Ala23.5 (84)28.6 (56)0.2325.3 (140)24.6 (197)28.0 (42)0.4425.1 (239)1.00 (Ref.)0.32
AlleleVal51.045.749.149.351.350.8
Ala49.054.30.0950.950.748.70.8549.20.36
  • Data are % (n). Control subjects, no diabetic nephropathy; case subjects, overt + incipient diabetic nephropathy.

  • *

    * Overall P values for differences in genotype and allele frequencies between Finnish and Swedish patients.

  • ORs and 95% CIs for each genotype using Ala/Ala as reference (Ref.), Finnish + Swedish control subjects versus Finnish + Swedish case subjects.

  • P values for differences between Finnish + Swedish control subjects and Finnish + Swedish case subjects.