Baseline measures of insulin secretion and sensitivity according to KCNJ11 E23K and ABCC8 A1369S genotypes in the DPP
| KCNJ11 E23K | E/E | E/K | K/K | P value (E/E vs. E/K)* | P value (E/E vs. K/K)* |
|---|---|---|---|---|---|
| n | 1,658 | 1,445 | 364 | ||
| Ins index [(μU/ml)/(mg/dl)] | 1.07 (0.94) | 1.04 (0.87) | 0.97 (0.79) | 0.046 | 0.003 |
| ISI [(μU/ml) × (mmol/l)]−1 | 0.161 (0.121) | 0.162 (0.124) | 0.169 (0.144) | 0.98 | 0.76 |
| Fasting insulin (μU/ml) | 24 (16) | 24 (17) | 23 (18) | 0.85 | 0.73 |
| ABCC8 A1369S | S/S | A/S | A/A | P value (S/S vs. A/S)* | P value (S/S vs. A/A)* |
|---|---|---|---|---|---|
| n | 1,635 | 1,424 | 378 | ||
| Ins index [(μU/ml)/(mg/dl)] | 1.07 (0.95) | 1.03 (0.86) | 0.97 (0.81) | 0.02 | <0.01 |
| ISI [(μU/ml) × (mmol/l)]−1 | 0.162 (0.121) | 0.162 (0.123) | 0.172 (0.145) | 0.87 | 0.67 |
| Fasting insulin (μU/ml) | 24 (17) | 24 (17) | 22 (17) | 0.73 | 0.88 |
Data are median (interquartile range). The number of subjects for whom full OGTT data were available to calculate the insulinogenic index and insulin sensitivity index are displayed; a few additional subjects had fasting values only, which were used to calculate insulin sensitivity index.
* Nominal two-sided P values are displayed; to correct for the number of hypotheses tested, a Bonferroni correction factor of ×5 can be applied (see text for details). Ins, insulinogenic; ISI, insulin sensitivity index.