TABLE 2

Baseline measures of insulin secretion and sensitivity according to KCNJ11 E23K and ABCC8 A1369S genotypes in the DPP

KCNJ11 E23K	E/E	E/K	K/K	P value (E/E vs. E/K)*	P value (E/E vs. K/K)*
n	1,658	1,445	364
Ins index [(μU/ml)/(mg/dl)]	1.07 (0.94)	1.04 (0.87)	0.97 (0.79)	0.046	0.003
ISI [(μU/ml) × (mmol/l)]⁻¹	0.161 (0.121)	0.162 (0.124)	0.169 (0.144)	0.98	0.76
Fasting insulin (μU/ml)	24 (16)	24 (17)	23 (18)	0.85	0.73

ABCC8 A1369S	S/S	A/S	A/A	P value (S/S vs. A/S)*	P value (S/S vs. A/A)*
n	1,635	1,424	378
Ins index [(μU/ml)/(mg/dl)]	1.07 (0.95)	1.03 (0.86)	0.97 (0.81)	0.02	<0.01
ISI [(μU/ml) × (mmol/l)]⁻¹	0.162 (0.121)	0.162 (0.123)	0.172 (0.145)	0.87	0.67
Fasting insulin (μU/ml)	24 (17)	24 (17)	22 (17)	0.73	0.88

Data are median (interquartile range). The number of subjects for whom full OGTT data were available to calculate the insulinogenic index and insulin sensitivity index are displayed; a few additional subjects had fasting values only, which were used to calculate insulin sensitivity index.
* Nominal two-sided P values are displayed; to correct for the number of hypotheses tested, a Bonferroni correction factor of ×5 can be applied (see text for details). Ins, insulinogenic; ISI, insulin sensitivity index.