TABLE 5

Risk of CAD associated with TNFAIP3 SNPs according to A1C and study population

BostonItalyBoston +Italy
A1C ≤7.0%A1C >7.0%A1C ≤7.0%A1C >7.0%A1C ≤7.0%A1C >7.0%
n229238124426353664
rs5029930
    C/C + A/C vs. A/A
OR (95% CI)3.32 (1.4–7.7)1.7 (0.9–3.3)2.44 (0.8–7.2)1.20 (0.7–2.0)2.90 (1.5–5.6)*1.40 (0.9–2.1)*
P value0.0060.0960.1290.530.00120.098
rs610604
    C/C + A/C vs. A/A
    OR (95% CI)3.87 (2.0–7.3)1.24 (0.7–2.1)2.20 (1.0–4.9)0.90 (0.6–1.4)3.00 (1.8–4.9)*1.05 (0.8–1.5)*§
    P value3.3 × 10−50.430.0530.638.3 × 10−60.83
  • Data are OR (95% CI). Twenty-five subjects (12 from Boston and 13 from Italy) for whom A1C values were not available were excluded from the analysis. All ORs are adjusted for age, sex, BMI, smoking status, and hypertension status. The ORs for Boston + Italy are also adjusted for study population.

  • * NS for difference in ORs between populations within A1C strata.

  • P = 0.015 for the difference in ORs between A1C strata in the Boston population.

  • P = 0.05 for the difference in ORs between A1C strata in the Italian population.

  • § P = 0.0008 for the difference in ORs between A1C strata in the two populations combined.

  • NS for difference between populations in the interaction between SNP and A1C strata.