TABLE 6

Haplotype frequencies in CAD+ case subjects and CAD control subjects in the two populations combined

rs5029930/ rs610604 haplotypesA1C ≤7.0% (n = 353)A1C >7.0% (n = 664)
CADCAD+Haploscore*P valueCADCAD+Haploscore*P value
AA0.7260.542−5.0344.8 × 10−70.6640.657−0.6710.51
AC0.2140.3272.7600.00580.2310.219−0.2050.82
CA0.0140.0613.1400.00170.0450.0440.7000.48
CC0.0460.0703.2800.00100.0600.0791.1420.25
  • Twenty-five subjects (12 from Boston and 13 from Italy) for whom A1C values were not available were excluded from the analysis.

  • * Haplotype-specific score for association with CAD computed by the Haplo.score program. Positive values denote association with increased risk, negative values with decreased risk.

  • Global P = 1.8 × 10−6.

  • Global P = 0.67.