TABLE 3

Cardiac collagen content

ControlSTZSTZ-IRB
Total collagen content Sirius Red (% AF)2.6 ± 0.47.5 ± 1.13.6 ± 0.8
Collagen type I content (% AF)0.53 ± 0.091.03 ± 0.21*0.28 ± 0.03
Collagen type III content (% AF)7.6 ± 0.917.5 ± 2.3*7.73 ± 1.1
  • Cardiac collagen content of controls, mice with STZ-induced diabetes, and diabetic mice treated with irbesartan (STZ-IRB), showing increased total collagen and collagen type 1 and type 3 content in STZ mice, normalized in STZ-IRB.

  • *

    * P < 0.05 vs. controls and STZ. AF, area fraction.