TABLE 2

Functional data

Wild type (n = 5)
aMPKα2−/− (n = 5)
GlucoseGlucose+oleateGlucoseGlucose+oleate
Ventricular pressure (mmHg)87 ± 7109 ± 785 ± 5118 ± 6
Heart rate (beats/min)358 ± 18317 ± 17365 ± 9337 ± 16
RPP (104 mmHg · beats−1 · min−1)2.9 ± 0.13.2 ± 0.12.9 ± 0.23.6 ± 0.2
+DP/dt (mmHg/s)3,818 ± 2294,088 ± 2643,778 ± 3564,533 ± 465
−DP/dt (mmHg/s)−2,719 ± 187−3,053 ± 131−2,513 ± 153−3,167 ± 141
QO2 (μmol O2 · min−1 · g−1 wet wt)6.4 ± 0.78.6 ± 0.7*6.0 ± 0.68.0 ± 1.0
QO2/RPP2.3 ± 0.32.7 ± 0.32.1 ± 0.32.3 ± 0.3
  • Data are means±SE. n, number of mice. Hearts were first perfused with glucose 11 mmol/l and then with glucose 5 and 0.4 mmol/l oleate. DP/dt, developed pressure per unit time; RPP, rate pressure product; QO2, oxygen consumption rate. No statistical difference between control and AMPKα2−/−.

  • *

    * P < 0.05, glucose vs. glucose + oleate.