TABLE 2

Stage 1 association results with P < 0.1

GeneTestAlleleORP value
HNF4Ars1884613G1.11 (0.97–1.27)0.05
GCKhCV329749A1.10 (0.99–1.19)0.07
GCKrs2284779C1.27 (1.01–1.59)0.04
GCKG(−30)AA1.15 (0.99–1.33)0.07
GCKrs10259649, rs741038, rs730497, rs2908287 rs2971667TTCCA1.09 (0.99–1.20)0.08
TCF1rs2649999C0.89 (0.78–1.01)0.07
TCF1rs2701175A0.87 (0.78–0.96)0.006
TCF1rs1920792T1.17 (1.06–1.30)0.002
TCF1GE117884_349G1.12 (1.01–1.25)0.03
TCF1GE117881_360A0.87 (0.79–0.97)0.009
TCF1rs1169289G0.90 (0.81–1.00)0.04
TCF1I27LL1.13 (1.01–1.25)0.02
TCF1rs1169292C0.91 (0.82–1.01)0.08
TCF1rs735396A0.89 (0.80–0.99)0.03
TCF1rs2258043, rs1920792G1.09 (0.99–1.21)0.09
TCF1GE117881_360CA0.87 (0.78–0.96)0.007
TCF1rs2649999, rs2244608,CT0.90 (0.79–1.02)0.1
TCF1rs2701175 GE117881_360CG1.11 (1.00–1.23)0.05
TCF1rs2701175, rs1920792CT1.13 (1.01–1.26)0.02
IPF1YamadaG4, rs2297316, rs2293943G0.88 (0.77–1.00)0.06
IPF1YamadaG4, rs9512918GT, DEL, C0.87 (0.75–1.00)0.04
TCF2rs11263755A1.13 (0.99–1.28)0.08
TCF2rs2285741A0.91 (0.82–1.01)0.08
TCF2rs3110641C1.18 (1.04–1.34)0.009
TCF2rs1859211C0.88 (0.76–1.02)0.10
TCF2rs757210, rs2285741, rs10962A1.10 (0.99–1.23)0.08
TCF2rs3110641, rs10962, rs3110641GGC1.11 (0.99–1.23)0.06
TCF2rs6422978, rs11263755, rs2285741GCA1.14 (1.02–1.27)0.02
TCF2rs10962 rs3110641AGGC1.12 (1.00–1.24)0.04
NEUROD1A45TT0.91 (0.82–1.01)0.06
  • Results given for all the MODY gene variants with tests with P < 0.1 in stage 1 samples. For all association results, see supplemental Appendix 3. All P values are two-tailed and uncorrected for multiple hypothesis testing. G(−30)A was tested by perfect proxy rs730497. HNF4α data is from Ref. 19; TCF1 data is from Ref. 22.