TABLE 2

Ca2+ transient characteristics in the presence of NAC or ebselen with or without 1.2 mmol/l palmitate

nΔF/F0D1/2 (ms)τ (ms)
Wild-type mice
    NAC123.8 ± 0.2165.1 ± 5.1154.7 ± 4.9
    NAC + palmitate123.4 ± 0.2177.5 ± 4.9149.5 ± 4.3
    Ebselen143.3 ± 0.3174.1 ± 3.5167.1 ± 7.5
    Ebselen + palmitate143.4 ± 0.3180.7 ± 5.9170.2 ± 10.3
ob/ob mice
    NAC153.2 ± 0.1154.8 ± 4.2158.4 ± 11.5
    NAC + palmitate153.5 ± 0.3138.5 ± 3.1*131.7 ± 4.6*
    Ebselen153.1 ± 0.2218.7 ± 8.3201.7 ± 9.4
    Ebselen + palmitate163.4 ± 0.2189.3 ± 6.4*183.6 ± 7.0
  • Data are means ± SE.

  • *

    * P < 0.05, palmitate vs. no palmitate within each group (wild-type or ob/ob). ΔF/F0, peak amplitude; τ, decay time constant; D1/2, half-width.