TABLE 1

Body composition, food intake, energy expenditure, and cardiovascular parameters in high fat–fed C57BL/6J mice chronically treated with vehicle or sildenafil plus l-arginine

VehicleSildenafil + l-arginine
n1413
Weight (g)32 ± 1.127.3 ± 0.6*
Fat (g)8.7 ± 1.04.6 ± 0.4*
Muscle (g)20.6 ± 0.319.9 ± 0.3*
Food consumption (g/day)3.0 ± 0.83.0 ± 0.8
Capillary density (number per mm2)423 ± 32494 ± 29
Arterial cGMP (pmol/ml)0.27 ± 0.092.14 ± 0.32*
Pulse (beats per min)646 ± 10632 ± 9
Systolic blood pressure (mmHg)109 ± 3108 ± 3
Left ventricular mass (mg/g body wt)3.8 ± 35.1 ± 0.2*
  • Data are means ± SE.

  • *

    * P < 0.05 vs. vehicle;

  • circulating cGMP levels and capillary density were determined from plasma taken during, and gastrocnemius muscle excised after, hyperinsulinemic-euglycemic clamps.