TABLE 2

Basal and clamp characteristics in high fat–fed C57BL/6J mice chronically treated with vehicle or sildenafil plus l-arginine

VehicleSildenafil + l-arginine
n78
Arterial glucose (mg/dl)
    Basal187 ± 9168 ± 5*
    Clamp163 ± 4174 ± 4
Insulin (μU/ml)
    Basal42 ± 1525 ± 8
    Clamp91 ± 1461 ± 5*
Insulin sensitivity index, or GIR/[insulin] (mg · ml · [kg · min · mU]−1)315 ± 75696 ± 93*
Endogenous Ra (mg · kg−1 · min−1)
    Basal13 ± 213 ± 1
    Clamp3 ± 5−4 ± 3
Rd (mg · kg−1 · min−1)
    Basal13 ± 214 ± 1
    Clamp29 ± 438 ± 3*
FFA (mmol/l)
    Basal1.03 ± 0.051.20 ± 0.07*
    Clamp0.52 ± 0.060.46 ± 0.07
  • Data are means ± SE. Values are for 5-h–fasted, conscious, unrestrained mice at least 5 days after surgical catheterization.

  • *

    * P < 0.05 vs. vehicle.