TABLE 3

Body composition, food consumption, energy expenditure, and cardiovascular parameters in high fat–fed C57BL/6J mice chronically treated with either vehicle or sildenafil

VehicleSildenafil
n1010
Weight (g)40.7 ± 1.636.5 ± 1.0*
Fat (g)15.7 ± 1.211.2 ± 0.7*
Muscle (g)23.3 ± 0.522.6 ± 0.6
Food consumption (g/day)2.8 ± 0.84.2 ± 0.4*
Arterial cGMP (pmol/ml)0.37 ± 0.091.72 ± 0.28*
Pulse (beats per min)587 ± 18644 ± 12*
Systolic blood pressure (mmHg)104 ± 3110 ± 3
Left ventricular mass (mg/g body wt)4.5 ± 0.35.0 ± 0.4
  • Data are means ± SE.

  • *

    * P < 0.05 vs. vehicle;

  • circulating cGMP levels were determined from plasma taken during hyperinsulinemic-euglycemic clamps.