TABLE 4

Basal and clamp characteristics in high fat–fed C57BL/6J mice chronically treated with either vehicle or sildenafil

VehicleSildenafil
n78
Arterial glucose (mg/dl)
    Basal172 ± 18150 ± 13
    Clamp156 ± 3152 ± 3
Insulin (μU/ml)
    Basal50 ± 826 ± 6*
    Clamp84 ± 1054 ± 9*
Insulin sensitivity index, or GIR/[insulin] (mg · ml · [kg · min · mU]−1)370 ± 54854 ± 101*
Endogenous Ra (mg · kg−1 · min−1)
    Basal12 ± 115 ± 1*
    Clamp3 ± 23 ± 1
Rd (mg · kg−1 · min−1)
    Basal12 ± 115 ± 1*
    Clamp33 ± 443 ± 2*
FFA (mmol/l)
    Basal1.88 ± 0.131.68 ± 0.09
    Clamp1.21 ± 0.131.02 ± 0.04
  • Data are means ± SE. Values are for 5-h–fasted, conscious, unrestrained mice at least 5 days after surgical catheterization.

  • *

    * P < 0.05 vs. vehicle.