TABLE 2

Hormone concentrations, insulin action, and insulin secretion indexes following ingestion of mixed meal and glucose alone

NFG/NGT group
NFG/IGT group
IFG/NGT group
IFG/IGT-D group
MealOGTTPMealOGTTPMealOGTTPMealOGTTP
Glucose (mmol/l)
    Fasting4.9 ± 0.14.9 ± 0.10.5014.9 ± 0.15.0 ± 0.10.4235.5 ± 0.15.5 ± 0.10.5205.8 ± 0.15.8 ± 0.10.540
    Area 0–240343 ± 22414 ± 290.060519 ± 58628 ± 420.145231 ± 28272 ± 330.365594 ± 55724 ± 580.109
Insulin (nmol/l)
    Fasting0.03 ± 0.00.03 ± 0.00.4390.03 ± 0.00.03 ± 0.00.8580.04 ± 0.00.04 ± 0.00.7980.05 ± 0.00.04 ± 0.00.403
    Area 0–24046 ± 924 ± 20.02248 ± 843 ± 70.59947 ± 1030 ± 60.09167 ± 545 ± 50.005
C-peptide (nmol/l)
    Fasting0.42 ± 0.040.41 ± 0.040.8460.42 ± 0.040.40 ± 0.040.7940.53 ± 0.070.58 ± 0.060.5970.57 ± 0.050.56 ± 0.060.889
    Area 0–240334 ± 34251 ± 210.044366 ± 32339 ± 340.565338 ± 50255 ± 500.142404 ± 21320 ± 240.011
Glucagon (pg/ml)
    Fasting57 ± 360 ± 50.60877 ± 1375 ± 70.90665 ± 762 ± 80.77778 ± 579 ± 70.913
    Area 0–2404,879 ± 1,305−1,548 ± 777<0.0052,145 ± 1,053−1,855 ± 1,5830.0473,015 ± 672−2,164 ± 812<0.005643 ± 938−3,486 ± 731<0.005
Insulin action
    Si23 ± 329 ± 30.02011 ± 217 ± 40.03417 ± 426 ± 40.0438 ± 211 ± 20.048
Insulin secretion
    Total51 ± 535 ± 3<0.00150 ± 636 ± 4<0.00568 ± 553 ± 50.01849 ± 330 ± 2<0.001
Disposition indexes
    Total958 ± 132929 ± 780.680471 ± 40547 ± 1210.2701,191 ± 2661,358 ± 2310.170401 ± 71324 ± 610.022
  • Data are means ± SE.