TABLE 1

Body and organ weight, blood pressure, and renal function of UNX-LZR and UNX-OZR rats after 8 weeks of treatment

UNX-LZR (n = 12)UNX-OZR
Placebo (n = 8)S18886-10 (n = 7)S18886-30 (n = 8)
Body wt (g)338 ± 5448 ± 13*427 ± 12429 ± 17
Body wt gain (g)167 ± 4282 ± 17267 ± 15274 ± 15
Kidney wt (g)2.15 ± 0.072.43 ± 0.09*2.36 ± 0.122.01 ± 0.07§
SBP (mmHg)91.7 ± 1.7116.9 ± 5.0*107.9 ± 2.9107.1 ± 2.4
Plasma creatinine (μmol/l)52.5 ± 1.044.6 ± 1.441.2 ± 1.144.7 ± 1.3
Creatinine clearance (ml/min)0.73 ± 0.061.14 ± 0.051.03 ± 0.060.99 ± 0.08
Plasma urea (mmol/l)8.0 ± 0.413.4 ± 0.511.0 ± 1.39.0 ± 0.4§
U-urea (mmol/24 h)4.8 ± 0.415.2 ± 1.212.1 ± 0.711.8 ± 1.4
Proteinuria (mg/24 h)6.0 ± 0.425.7 ± 1.822.6 ± 7.716.2 ± 4.0
Diuresis (ml/24h)9.0 ± 1.141.9 ± 3.236.7 ± 6.329.2 ± 2.8
U-TGF-β1 (nmol/24h)100 ± 20694 ± 207195 ± 60183 ± 45
U-TxB2/creatinine (ng/μmol)0.55 ± 0.061.46 ± 0.270.82 ± 0.050.71 ± 0.04
  • Data are means ± SE. SBP, systolic blood pressure; U-urea, urinary excretion of urea; U-TGF-β1, urinary excretion of transforming growth factor-β1; U-TxB2, urinary excretion of thromboxane B2;

  • *

    * P < 0.05 vs. LZR;

  • P < 0.01 vs. LZR (Wilcoxon's test);

  • P < 0.05 vs. OZR-PLAC;

  • §

    § P < 0.01 vs. OZR-PLAC (Dunnett's test).