TABLE 2

Plasma total protein, glucose and lipid concentration, and data characterizing oxidative status in UNX-LZR and UNX-OZR rats after 8 weeks of treatment

UNX-LZR (n = 12)UNX-OZR
Placebo (n = 8)S18886-10 (n = 7)S18886-30 (n = 8)
Glucose (mmol/l)15.7 ± 1.725.2 ± 1.3*23.3 ± 1.326.8 ± 1.5
Cholesterol (mmol/l)2.30 ± 0.123.36 ± 0.12*3.72 ± 0.163.58 ± 0.31
Triglycerides (mmol/l)0.98 ± 0.093.98 ± 0.41*3.92 ± 0.693.50 ± 0.59
Total protein (g/l)62.1 ± 1.059.1 ± 1.262.4 ± 0.862.6 ± 1.6
WBC (×103/μl)4.61 ± 0.436.01 ± 0.35*6.27 ± 1.046.28 ± 1.91
AOPPs (μmol/l)57 ± 5171 ± 23*179 ± 37127 ± 14
SOD (units/g hemoglobin)2,299 ± 912,419 ± 882,757 ± 1572,843 ± 122
GPX (units/g hemoglobin)1,145 ± 1351,008 ± 421,486 ± 841,568 ± 119
  • Data are means ± SE.

  • *

    * P < 0.01 vs. LZR (Wilcoxon's test);

  • P < 0.01 vs. OZR-PLAC (Dunnett's test).