TABLE 3

Parameters of glomerular geometry in UNX-LZR and UNX-OZR rats after 8 weeks of treatment

UNX-LZR (n = 12)UNX-OZR
Placebo (n = 8)S18886-10 (n = 7)S18886-30 (n = 8)
Mesangiolysis score0.30 ± 0.0280.46 ± 0.0450.31 ± 0.0350.29 ± 0.017§
Glomerulosclerosis score0.25 ± 0.0280.32 ± 0.0440.25 ± 0.0250.22 ± 0.026
Tubulointerstitial damage score0.74 ± 0.170.85 ± 0.360.58 ± 0.190.58 ± 0.17
Vascular damage score0.05 ± 0.030.23 ± 0.14*0.03 ± 0.030.16 ± 0.23
Glomerular cell number61.0 ± 1.9656.8 ± 2.2759.8 ± 2.9955.0 ± 1.11*
Maximal glomerular diameter (μm)134 ± 1.7149 ± 2.1157 ± 3.9152 ± 3.0
Minimal glomerular diameter (μm)108 ± 1.1121 ± 0.8129 ± 2.5124 ± 3.1
Mean glomerular tuft area (μm2)10,335 ± 22712,152 ± 23512,784 ± 43111,692 ± 410
Mean glomerular tuft volume (μm3)1,321 ± 431,682 ± 491,818 ± 941,590 ± 83
  • Data are means ± SE.

  • *

    * P < 0.05 vs. LZR;

  • P < 0.01 vs. LZR (Wilcoxon test);

  • P < 0.05 vs. OZR-PLAC;

  • §

    § P < 0.01 vs. OZR-PLAC;

  • P < 0.05 vs. OZR-S18886-10;

  • P < 0.01 vs. OZR-S18886-10 (Dunnett's test).