TABLE 1

SNPs in or near PVT1 associated with diabetic ESRD

MarkerPosition (Mb)Position (LDU)Genotypen (%) case subjectsn (%) control subjectsOR (95% CI)P
rs11993333129.0616691.4113CC63 (62)41 (40)
CT34 (33)49 (48)
TT5 ( 5)13 (13)2.10 (1.33–3.29)0.001317
rs10808565129.0765941.4452TT84 (90)59 (69)
TC8 (9)22 (26)
CC1 (1)4 (5)3.34 (1.59–7.02)0.001442
rs3815871129.077761.4452GG87 (84)66 (64)
GC15 (15)32 (31)
CC1 (1)5 (5)2.75 (1.50–5.03)0.001093
rs13447075129.0797721.4505CC91 (88)67 (70)
CA12 (12)26 (27)
AA1 (1)3 (3)2.67 (1.37–5.19)0.003774
rs10087240129.0817561.4655CC85 (85)58 (69)
CT15 (15)24 (29)
TT0 (0)2 (2)2.57 (1.29–5.11)0.00721
rs2720709129.1275382.4432AA30 (29)9 (9)
AG54 (51)50 (49)
GG21 (20)44 (43)2.57 (1.66–3.96)0.000021
rs2720659129.1299862.4432AA56 (62)26 (30)
AG28 (31)40 (45)
GG7 (8)22 (25)2.73 (1.73–4.30)0.000015
rs2720660129.1304242.4455GG72 (70)44 (44)
GA27 (26)43 (43)
AA4 (4)14 (14)2.49 (1.56–3.98)0.000124
NA129.1309672.4477CC68 (68)88 (85)
CA30 (30)15 (15)
AA2 (2)0 (0)0.36 (0.19–0.71)0.002845
rs2720662129.1322032.4477TT62 (60)28 (27)
TC34 (33)53 (51)
CC7 (7)22 (21)2.89 (1.85–4.51)0.000003
rs1499373129.1338472.4600CC21 (21)44 (44)
CG50 (50)46 (46)
GG30 (30)10 (10)0.41 (0.26–0.62)0.000036
rs2648875129.1413432.4600AA63 (61)28 (27)
AG33 (32)54 (52)
GG7 (7)22 (21)2.97 (1.90–4.65)0.000002
rs2648876129.1421482.4603GG71 (76)45 (54)
GA19 (20)30 (36)
AA4 (4)9 (11)2.14 (1.29–3.55)0.003225
rs2250888129.151562.4603TT41 (41)20 (21)
TC46 (46)55 (57)
CC12 (12)22 (23)2.01 (1.30–3.11)0.001623
rs2720666129.1526412.7158AA87 (84)70 (70)
AG16 (16)27 (27)
GG0 (0)3 (3)2.38 (1.25–4.53)0.008602
rs2720667129.1527662.7493AA87 (84)72 (69)
AG16 (16)29 (28)
GG0 (0)3 (3)2.45 (1.29–4.66)0.006183
rs1499368129.1637712.7493TT40 (38)21 (20)
TC52 (50)58 (56)
CC12 (12)25 (24)2.01 (1.31–3.08)0.00131
rs1499367129.164162.7493AA40 (39)21 (21)
AG50 (49)57 (56)
GG12 (12)24 (24)1.98 (1.29–3.04)0.001705
rs3931283129.1799153.1601CC75 (75)50 (52)
CT24 (24)38 (39)
TT1 (1)9 (9)2.70 (1.59–4.59)0.000252
rs4526320129.1822693.3900CC82 (80)62 (62)
CG20 (19)32 (32)
GG1 (1)6 (6)2.29 (1.31–4.00)0.003499
rs4733595129.1868373.6957GG82 (79)62 (60)
GA21 (20)36 (35)
AA1 (1)6 (6)2.40 (1.38–4.16)0.001827
rs2608030129.2342614.4565CC46 (45)70 (67)
CT49 (48)28 (27)
TT8 (8)6 (6)0.52 (0.32–0.82)0.004991
rs7465157129.3245884.8513GG82 (79)62 (60)
GA22 (21)38 (37)
AA0 (0)4 (4)2.57 (1.44–4.59)0.001414
  • Genotypes for each marker were assessed in 105 diabetic individuals with ESRD and 102 diabetic control subjects. Chromosomal position is based on Build 35.1. The number of individuals (n) per genotype is shown with the frequency (%) for each group. ORs shown were calculated using an analytical model that assumed an additive allele effect on the logarithm of the odds and is expressed per copy of the allele listed first.