TABLE 1

ARHGEF11 SNPs significantly associated with type 2 diabetes and type 2 diabetes/IGT in the Amish

SNP IDNCBI locationSNP typeMinor alleleMinor allele frequencyLocation (SNP type)T2D vs. NGT
T2D/IGT vs. NGT
POR (95% CI)POR (95% CI)
RS3187878153717717A/GG0.19Exon 41 (3′ UTR)0.091.52 (0.94–2.47)0.011.61 (1.09–2.38)
RS6676153717891C/TT0.20Exon 41 (3′ UTR)0.211.35 (0.14–12.5)0.021.57 (1.06–2.32)
RS2275198153719954A/GA0.19Intron 390.281.31 (0.79–2.16)0.031.54 (1.03–2.30)
RS945508153720154T/CT0.47Exon 39 (R1467H)0.040.66 (0.44–0.98)0.170.81 (0.59–1.10)
RS3818807153722376A/TT0.20Intron370.221.35 (0.17–11.0)0.021.56 (1.06–2.31)
RS2275199153722768C/TT0.20Exon 36 (N1207N)0.151.44 (0.87–2.37)0.011.69 (1.15–2.50)
RS2275201153728111C/TT0.20Intron 290.181.39 (0.85–2.27)0.021.60 (1.07–2.38)
RS2275202153734293C/TT0.05Intron 220.120.47 (0.18–1.25)0.0050.33 (0.15–0.75)
RS2275204153738508A/GG0.19Intron 200.261.34 (1.03–1.74)0.041.52 (1.02–2.28)
RS1572409153741849A/TT0.20Intron 170.121.34 (0.83–2.17)0.031.54 (1.04–2.30)
RS12136088153754485G/TT0.23Intron 80.0021.56 (0.97–2.52)0.0031.77 (1.21–2.58)
RS1336147153757272A/GG0.24Intron 80.091.48 (0.94–2.34)0.0091.63 (1.13–2.37)
RS1006168153759971A/CC0.24Intron 60.031.67 (1.05–2.66)0.011.63 (1.13–2.37)
RS12141806153761026A/TT0.23Intron 60.051.60 (1.01–2.54)0.0071.68 (1.14–2.46)
RS1007604153761953G/TT0.23Intron 50.151.39 (0.89–2.17)0.021.54 (1.08–2.22)
RS1572416153765127A/CA0.24Intron 30.081.49 (0.93–2.38)0.0091.64 (1.14–2.38)
RS6427339153767340C/TT0.42Intron 20.021.66 (1.08–2.55)0.0061.60 (1.14–2.25)
RS6427340153767457C/TC0.41Intron 20.0051.82 (1.20–2.70)0.00081.79 (1.27–2.50)
RS7541702153767506C/TC0.23Intron 20.061.56 (0.98–2.50)0.0091.67 (1.12–2.44)
RS1572414153776947C/TC0.24Intron 10.081.49 (0.93–2.38)0.0091.64 (1.14–2.38)
RS884891153782676C/TC0.24Intron 10.091.47 (0.93–2.38)0.0091.61 (1.12–2.33)
RS822581153789298A/GG0.24Intron 10.081.49 (0.94–2.34)0.0091.63 (1.13–2.37)
RS703152153790978A/GA0.24Intron 10.091.48 (0.82–2.67)0.011.61 (1.12–2.32)
RS822576153804644C/TC0.47Intron 10.061.45 (0.01–100)0.011.47 (1.08–2.00)
RS1336146153815516C/TT0.47Intron 10.061.43 (0.97–2.10)0.021.46 (1.07–1.99)
RS822570153820575A/GG0.47Intron 10.061.44 (0.02–127)0.021.46 (1.07–1.99)
RS822572153827775A/GG0.47Exon 1 (5′ UTR)0.081.40 (0.96–2.06)0.021.45 (1.07–1.97)
RS861086153829497A/GG0.0075′ Flank0.11312.5 (11.1–16.7)0.0112.5 (10.0–14.3)
RS822585153830278A/TA0.415′ Flank0.011.69 (0.36–8.33)0.011.52 (1.09–2.08)
RS1750810153850563C/GC0.475′ Flank0.071.43 (0.005–500)0.011.47 (1.09–2.00)
  • NCBI location is based on Build 35.1. OR > 1.00 denotes that the minor allele is the risk allele, while OR < 1.00 denotes that the major allele is the risk allele. T2D, type 2 diabetes; UTR, untranslated region.