TABLE 2

Association analysis of ARHGEF11 haplotypes with type 2 diabetes and type 2 diabetes/IGT and glucose AUC during an oral glucose tolerance test

HaplotypeHaplotype frequency
T2D vs. NGT
T2D/IGT vs. NGT
Glucose AUC
T2DIGTNGTHaploscorePHaploscorePHaploscoreP
AGAAGCTTA0.710.670.79−2.350.019−3.710.0002−3.200.001
TGAAGCTTA0.0080.0110.0030.840.401.360.180.540.59
ATAAGCTTA0.0040.0260.0030.150.881.740.0821.690.091
ATGTTACCG0.0500.0440.0281.730.0831.830.0681.620.11
TTGTTACCG0.220.250.171.550.122.560.0102.520.012
  • Haplotype frequencies were estimated with Haploscore for the nine positively associated ARHGEF11 SNPs by case-control analysis and transmissional disequilibrium test (RS1572409, RS12136088, RS1336147, RS12141806, RS1007604, RS1572416, RS1572414, RS884891, and RS822581). Global P value for test = 0.28, 0.006, and 0.008 for type 2 diabetes vs. NGT, type 2 diabetes/IGT vs. NGT, and glucose AUC, respectively. Bold face data denote statistical significance. T2D, type 2 diabetes.