TABLE 2

Plasma and muscle metabolite data during the 120-min [2-13C]acetate infusion

Insulin-sensitive controlInsulin-resistant offspring
Plasma [acetate] (mmol/l)0.93 ± 0.120.93 ± 0.05
Plasma [2-13C]acetate APE (%)80.8 ± 2.4587.42 ± 0.80*
Muscle C2-glutamate APE (%)1.20 ± 0.391.04 ± 0.20
Muscle C4-glutamate APE (%)2.52 ± 0.832.13 ± 0.43
VTCA (nmol · g−1 · min−1)96.1 ± 16.359.8 ± 5.1
Vac/VTCA (%)3.4 ± 1.12.9 ± 0.6
  • Data are means ± SE. APE, atom percent excess.

  • *

    * P < 0.01;

  • calculated from C2-glutamate assuming 5% anaplerosis;

  • P < 0.05.