TABLE 2

Sample size for diabetic nephropathy as dichotomous trait genome scan and urine ACR as quantitative trait genome scan

EthnicityPedigreesDichotomous trait
Quantitative trait
Full sibling pairs
Half-sibling pairs
Avuncular
Cousin
Full sibling pairs
Concordant affectedDiscordantConcordant unaffectedConcordant affectedDiscordantConcordant unaffectedConcordant affectedConcordant affectedNA
African American965127246040168
American Indian32271512200069
European American541729312000126
Mexican American1961228716431104520
Total3782171582211131144883
  • Concordant affected means that both individuals in the sibling pair have diabetes and diabetic nephropathy. Discordant means that both individuals in the sibling pair have diabetes, one has diabetic nephropathy, and the other is unaffected with diabetic nephropathy after diabetes duration of at least 10 years. Concordant unaffected means that both individuals in the sibling pair have diabetes with a duration of at least 10 years, and neither has diabetic nephropathy. NA, not applicable to quantitative traits.