TABLE 4

Mean allele sharing for affected and discordant sibling pairs at the peak locations for diabetic nephropathy

Ethnic groupChromosomeDiscordant sibling pairs mean sharing*P valueAffected sibling pairs mean sharing*P value
African American70.380.00130.580.0248
American Indian100.270.00070.580.0498
American Indian140.300.02870.560.1733
European American180.400.03080.570.1959
  • *

    * Under the null hypothesis, sibling pairs should share 50% of their genome identical by descent. At a disease locus, discordant siblings should share <50%, and affected siblings should share >50%.