TABLE 3

An initial association of NPY2R with obesity in men from the screening panels

European American
Polish
Combined data*
MAFPORMAFPORPOR (95% CI)Permuted P§
rs28804160.180.160.830.260.140.790.0440.82 (0.67–0.99)0.99
rs23426760.390.051.250.380.081.300.00871.27 (1.06–1.51)0.76
rs126496410.390.021.300.380.141.240.00481.28 (1.08–1.51)0.57
rs110999920.310.041.280.330.101.290.00761.28 (1.07–1.54)0.71
hCV15269950.300.021.340.320.061.340.00191.34 (1.11–1.62)0.33
rs125073960.110.110.770.150.290.810.0570.79 (0.99–1.63)1.00
rs68575300.390.0061.370.390.091.280.00131.34 (1.12–1.59)0.22
CCAGAAG0.380.021.320.410.041.360.0021.34 (1.11–1.61)0.33
CTCAGAA0.410.130.850.350.680.940.1400.88 (0.74–1.03)1.00
GTCAGAA0.060.621.110.040.370.820.8150.97 (0.73–1.29)1.00
  • *

    * Results combined using a Mantel-Haenszel test.

  • P value from χ2 test using an allelic model.

  • Odds ratio (OR) for the effect of the minor allele of the SNP or the effect of the indicated haplotype vs. all others.

  • §

    § Using 1,000 permutations.

  • The first seven SNPs are the tag SNPs from the most associated block of NPY2R. The haplotypes are denoted by the alleles of the seven SNPs above that which they carry.

  • The first haplotype is associated with increased risk or obesity, the second is slightly protective for obesity, and the third was found be associated with type 2 diabetes in further samples. MAF, minor allele frequency.