TABLE 4

Association of NPY2R SNPs to BMI analyzed as a continuous trait

FHS men
Scandinavian men
Unrelated men combined
Scandinavian trios
MAFP*βMAFPβPβMAFPDirection§
rs28804160.190.41−0.0520.220.26+0.0620.80+0.0100.240.97+
rs23426760.390.18+0.0660.440.72−0.0170.58+0.0190.470.46
rs126496410.370.10+0.0820.430.24−0.0570.82+0.0080.470.90
rs110999920.280.46+0.0410.340.06+0.1330.07+0.0790.380.81
hCV15269950.270.59+0.0290.340.33+0.0480.34+0.0350.370.94
rs125073960.110.58+0.0410.130.05+0.1340.07+0.0900.130.59+
rs68575300.380.18+0.0660.420.36−0.0430.85+0.0060.360.46
CCAGAAG0.280.73+0.0190.330.53+0.030.54+0.0220.370.67
CTCAGAA0.430.36−0.0440.350.77−0.0140.47−0.0240.290.85+
GTCAGAA0.070.08−0.1730.090.79−0.0210.08−0.1080.120.37
  • *

    * P value for the linear regression of age-adjusted score against genotype coded as 0, 1, or 2 denoting the number of minor allele or haplotype copies carried by an individual.

  • For the regression coefficient, β, a positive value indicates that the minor allele is associated with a higher age-adjusted score.

  • The combined results were generated by performing linear regression on the two datasets combined.

  • §

    § The direction is given a “+” if the minor allele is associated with higher age-adjusted score. MAF, minor allele frequency.