TABLE 5

Association of SNPs in NPY2R with BMI in men in all samples

European-derived replication*
African-American replication
All replication samples
All samples§
PORFrequencyPORPOR (95% CI)POR (95% CI)
rs44675080.110.850.950.170.90 (0.76–1.05)
rs99998200.230.031.460.720.97 (0.84–1.13)
rs100226850.020.460.690.460.69 (0.26–1.83)
rs76737010.130.611.120.350.93 (0.79–1.08)
rs76712130.110.631.120.380.93 (0.79–1.09)
rs126419820.110.391.220.460.94 (0.81–1.10)
rs93079280.160.641.090.641.09 (0.75–1.59)
rs68491150.240.900.980.900.98 (0.71–1.35)
rs28804160.341.110.070.680.890.451.08 (0.89–1.31)0.390.94 (0.82–1.08)
rs23426760.411.070.670.950.990.501.05 (0.91–1.22)0.0261.14 (1.02–1.27)
rs23426750.300.700.940.700.94 (0.70–1.28)
rs126496410.911.010.640.861.030.841.01 (0.88–1.18)0.0441.12 (1.00–1.25)
rs110999920.471.070.230.421.150.311.09 (90.93–1.28)0.0101.17 (1.04–1.32)
rs68502890.100.110.690.0131.24 (1.05–1.47)
rs102129380.090.500.850.500.85 (0.52–1.37)
hCV15269950.321.100.100.120.690.731.03 (0.87–1.22)0.0171.17 (1.03–1.32)
rs125073960.021.350.050.320.720.071.25 (0.98–1.58)0.961.00 (0.85–1.19)
rs68575300.791.020.740.620.920.641.04 (0.89–1.21)0.0141.15 (1.03–1.29)
CCAGAAG**0.541.060.0081.19 (1.05–1.36)
CTCAGAA**0.230.900.0570.89 (0.79–1.00)
GTCAGAA**0.180.810.270.89 (0.72–1.10)
  • The tag SNPs were tested in men from three European-derived and two African-American panels. The European-derived minor allele for each SNP was tested.

  • *

    * Combined data from a Mantel-Haenszel test in men for the Framingham, Scandinavian-unrelated, and Scandinavian trios panels.

  • Combined data for GCI and Maywood African-American panels.

  • Combined data for European-derived and African-American replication panels.

  • §

    § Combined data from all panels tested for association with BMI: screening and replication.

  • Frequency of allele tested.

  • Minor alleles are different in the African-American panels compared with the European-derived samples. Data for the minor allele in the European-derived samples are reported.

  • **

    ** The obesity-risk, protective, and diabetes-risk haplotypes were only evaluated in the European-derived samples due to differences in linkage disequilibrium in the African-American population.