TABLE 6

Association of SNPs and haplotypes in NPY2R with type 2 diabetes in male case-control subjects

Scandinavian family based
Scandinavian case-control
Swedish
French Canadian
European American
Polish
Combined data
MAFPOR*MAFPORMAFPORMAFPORMAFPORMAFPORPOR (95% CI)Permuted P
rs28804160.250.221.210.270.011.450.210.391.150.220.121.570.190.141.170.250.231.155.75 × 10−41.22 (1.09–1.36)0.024
rs23426760.461.001.000.471.001.000.390.181.180.420.830.950.400.930.990.380.170.870.8120.99 (0.90–1.09)1.00
rs126496410.460.671.060.470.830.970.390.051.300.420.891.040.400.740.970.380.140.860.9181.00 (0.91–1.09)1.00
rs110999920.360.780.960.370.631.060.30.021.380.310.730.900.310.400.860.320.460.930.3711.05 (0.95–1.15)0.93
hCV15269950.360.321.170.370.691.060.290.031.350.310.690.900.310.401.060.320.460.930.2081.07 (0.97–1.18)1.00
rs125073960.140.670.910.140.491.130.120.480.870.10.841.100.110.591.070.150.241.180.4241.06 (0.92–1.22)1.00
rs68575300.450.840.970.460.911.010.370.031.330.430.800.940.401.000.970.380.150.870.9921.00 (0.91–1.10)1.00
CCAGAAG0.350.871.030.370.831.030.290.021.370.300.770.920.310.931.010.320.471.080.1771.07 (0.97–1.18)0.84
CTCAGAA0.290.330.860.260.010.710.410.030.770.350.230.730.400.630.960.370.270.890.0020.86 (0.78–0.95)0.061
GTCAGAA0.100.0251.730.120.0061.730.090.041.640.120.081.840.080.431.120.090.551.111.73 × 10−41.36 (1.16–1.59)0.029
  • *

    * Odds ratio (OR) for developing type 2 diabetes with the minor allele.

  • Calculated using 1,000 permutations. MAF, minor allele frequency.