TABLE 1

Plasma concentrations of individual amino acids at baseline (0 min) and during amino acid infusion after administration of rapamycin or placebo (360 min)

Amino acidsTime (min)Rapamycin
Placebo
μmol/lFold change vs. 0 minμmol/lFold change vs. 0 min
Alanine0362 ± 37372 ± 38
3601,414 ± 53*3.91,291 ± 55*3.5
Arginine0113 ± 7108 ± 7
360423 ± 13*3.7431 ± 13*4.0
Asparagine057 ± 251 ± 1
360171 ± 7*3.0165 ± 7*3.2
Citrulline041 ± 342 ± 3
36078 ± 4*1.979 ± 5*1.9
Glutamine0652 ± 21638 ± 22
360883 ± 911.4940 ± 20*1.5
Glutamate027 ± 328 ± 4
36057 ± 8§2.164 ± 8§2.3
Glycine0252 ± 15259 ± 24
360928 ± 36*3.7922 ± 43*3.6
Histidine090 ± 389 ± 3
360262 ± 12*2.9267 ± 11*3.0
Isoleucine080 ± 370 ± 2
360169 ± 8*2.1168 ± 12*2.4
Leucine0154 ± 6139 ± 5
360357 ± 16*2.3354 ± 20*2.6
Methionine040 ± 235 ± 2
360205 ± 8*5.1202 ± 9*5.8
Phenylalanine058 ± 253 ± 3
360181 ± 6*3.1180 ± 8*3.4
Serine0129 ± 8117 ± 5
360264 ± 19*2.0253 ± 14*2.2
Taurine035 ± 138 ± 2
36046 ± 1*1.350 ± 3*1.3
Threonine0156 ± 11135 ± 8
360416 ± 17*2.7380 ± 7*2.8
Tryptophan051 ± 249 ± 2
36093 ± 5*1.891 ± 4*1.9
Tyrosine067 ± 262 ± 3
36066 ± 51.053 ± 40.9
Valine0273 ± 19247 ± 10
360444 ± 17*1.6431 ± 21*1.7
  • Data are means ± SE of eight healthy subjects who underwent somatostatin-insulin clamp tests.

  • *

    * P < 0.001 vs. corresponding baseline value.

  • P < 0.05 vs. RAPA.

  • P < 0.05 vs. corresponding baseline value.

  • §

    § P < 0.01 vs. corresponding baseline value.