TABLE 1

Regions displaying multipoint LOD scores ≥1 in the current cohort and other studies of fasting glucose or type 2 diabetes

LOD scores for fasting glucose
Chr.MarkersRegionsNonadjustedAdjusted for age and sexAdjusted for age, sex, and BMICandidate genes
2D2S3672p211.00PRKCE, SOS1, ARHQ
D2S22592p161.15
D2S1422q231.782.073.00GPD2, IGRP
D2S23302q24.11.612.001.98
6D6S2576p12–p111.11
7D7S6407q331.661.18
D7S6847q342.092.032.03
D7S6617q351.581.391.70
8D8S5148q24.131.661.661.28
11D11S404611p15.52.021.991.33SUR, Kir6.2, INS
D11S133811p15.51.681.44
D11S90211p15–p131.41
D11S90411p14–p131.251.02
D11S419111p13–q111.281.30
D11S131411q13–q141.491.35
D11S93711q13–q141.27
17D17S83117p13.32.12GLUT4
D17S79817q121.40
Results from other studies
LOD scores
Phenotypes and populations
Reference
2.28 at 2p21–p16Type 2 diabetes in EuropeansVionnet et al. (15)
1.25 at 2q23–q24Type 2 diabetes in EuropeansVionnet et al. (15)
2.61 at 2q24Type 2 diabetes in AustraliansBusfield et al. (16)
1.41 at 8q24Type 2 diabetes in the U.K.Wiltshire et al. (17)
0.9 at 11p15.1Type 2 diabetes in the NetherlandsVan Tilburg et al. (18)
11p15.1Fasting glucose in the Framingham Heart StudyChen et al. (25)
  • ARHQ, Ras homolog gene family, member Q; Chr., chromosome; GPD2, mitochondrial glycerophosphate dehyfrogenase; IGRP, islet-specific glucose-6-phosphate catalytic subunit–related protein; INS, insulin; PRKCE, protein kinase C epsilo; SOS1, son of sevenless drosophila homolog 1; SUR, sulfonylurea receptor.