Regions displaying multipoint LOD scores ≥1 in the current cohort and other studies of fasting glucose or type 2 diabetes
| LOD scores for fasting glucose | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chr. | Markers | Regions | Nonadjusted | Adjusted for age and sex | Adjusted for age, sex, and BMI | Candidate genes | ||||||
| 2 | D2S367 | 2p21 | 1.00 | PRKCE, SOS1, ARHQ | ||||||||
| D2S2259 | 2p16 | 1.15 | ||||||||||
| D2S142 | 2q23 | 1.78 | 2.07 | 3.00 | GPD2, IGRP | |||||||
| D2S2330 | 2q24.1 | 1.61 | 2.00 | 1.98 | ||||||||
| 6 | D6S257 | 6p12–p11 | 1.11 | |||||||||
| 7 | D7S640 | 7q33 | 1.66 | 1.18 | ||||||||
| D7S684 | 7q34 | 2.09 | 2.03 | 2.03 | ||||||||
| D7S661 | 7q35 | 1.58 | 1.39 | 1.70 | ||||||||
| 8 | D8S514 | 8q24.13 | 1.66 | 1.66 | 1.28 | |||||||
| 11 | D11S4046 | 11p15.5 | 2.02 | 1.99 | 1.33 | SUR, Kir6.2, INS | ||||||
| D11S1338 | 11p15.5 | 1.68 | 1.44 | |||||||||
| D11S902 | 11p15–p13 | 1.41 | ||||||||||
| D11S904 | 11p14–p13 | 1.25 | 1.02 | |||||||||
| D11S4191 | 11p13–q11 | 1.28 | 1.30 | |||||||||
| D11S1314 | 11q13–q14 | 1.49 | 1.35 | |||||||||
| D11S937 | 11q13–q14 | 1.27 | ||||||||||
| 17 | D17S831 | 17p13.3 | 2.12 | GLUT4 | ||||||||
| D17S798 | 17q12 | 1.40 | ||||||||||
| Results from other studies | ||||
|---|---|---|---|---|
| LOD scores | Phenotypes and populations | Reference | ||
| 2.28 at 2p21–p16 | Type 2 diabetes in Europeans | Vionnet et al. (15) | ||
| 1.25 at 2q23–q24 | Type 2 diabetes in Europeans | Vionnet et al. (15) | ||
| 2.61 at 2q24 | Type 2 diabetes in Australians | Busfield et al. (16) | ||
| 1.41 at 8q24 | Type 2 diabetes in the U.K. | Wiltshire et al. (17) | ||
| 0.9 at 11p15.1 | Type 2 diabetes in the Netherlands | Van Tilburg et al. (18) | ||
| 11p15.1 | Fasting glucose in the Framingham Heart Study | Chen et al. (25) | ||
ARHQ, Ras homolog gene family, member Q; Chr., chromosome; GPD2, mitochondrial glycerophosphate dehyfrogenase; IGRP, islet-specific glucose-6-phosphate catalytic subunit–related protein; INS, insulin; PRKCE, protein kinase C epsilo; SOS1, son of sevenless drosophila homolog 1; SUR, sulfonylurea receptor.