TABLE 1

Means ± SEM for measures of body composition, fasting and OGTT insulin and glucose concentrations, and measures of insulin secretion, insulin sensitivity, and β-cell function by genotype in 1,697 Europids for the rs7903146 TCF7L2 gene variant

C/CC/TT/TP
n830699147
BMI (kg/m2)27.0 ± 0.226.8 ± 0.226.6 ± 0.40.24
Fat percentage32.0 ± 0.231.8 ± 0.231.9 ± 0.50.61
Waist circumference (cm)92.9 ± 0.492.5 ± 0.491.3 ± 0.90.21
Fasting insulin (pmol/l)49.5 ± 0.948.9 ± 1.048.6 ± 2.10.60
Insulin AUC (pmol/l)*616 ± 11594 ± 12621 ± 260.54
Fasting glucose (pmol/l)5.49 ± 0.025.54 ± 0.035.61 ± 0.060.042
Glucose AUC (pmol/l)*15.0 ± 0.115.3 ± 0.115.8 ± 0.30.013
IGR at 30 min88.6 ± 2.586.1 ± 2.788.4 ± 5.90.70
IGR at 60 min134.0 ± 4.5120.2 ± 4.5108.5 ± 8.60.0035
Fasting intact proinsulin (pmol/l)3.56 ± 0.073.89 ± 0.084.46 ± 0.200.00000047
Fasting 32,33 split proinsulin (pmol/l)3.85 ± 0.104.06 ± 0.114.69 ± 0.280.0028
Fasting A1C (%)5.35 ± 0.025.38 ± 0.025.46 ± 0.040.012
HOMA-B83.3 ± 1.181.0 ± 1.277.7 ± 2.40.028
HOMA-S90.1 ± 1.691.3 ± 1.892.9 ± 4.00.45
  • Means are geometric means. All phenotypes were adjusted for age, sex, and BMI, except BMI and fat percentage, which were adjusted for age and sex. AUC, area under the curve; HOMA-B, homeostasis model assessment of β-cell function.