TABLE 1

Biometric and echocardiographic parameters of mice fed low- or high-fat diet for 5 months

FVB-LFFVB-HFMT-LFMT-HF
Body weight (g)26.27 ± 0.5831.56 ± 0.83*27.06 ± 0.4730.07 ± 1.02*
Liver weight (g)1.40 ± 0.071.56 ± 0.081.46 ± 0.061.53 ± 0.12
Kidney weight (g)0.34 ± 0.030.43 ± 0.020.38 ± 0.030.43 ± 0.03
Plasma insulin (ng/ml)0.16 ± 0.017.31 ± 0.53*0.20 ± 0.047.01 ± 0.92*
Diastolic blood pressure (mmHg)72.8 ± 4.882.4 ± 4.671.8 ± 6.581.5 ± 7.9
Systolic blood pressure (mmHg)101.8 ± 6.9115.0 ± 5.399.6 ± 8.5112.8 ± 7.4
Heart rate (bpm)410 ± 7429 ± 15439 ± 34452 ± 13
Wall thickness (mm)0.84 ± 0.030.87 ± 0.040.97 ± 0.070.87 ± 0.05
EDD (mm)2.73 ± 0.072.81 ± 0.142.37 ± 0.172.77 ± 0.13
ESD (mm)1.43 ± 0.091.79 ± 0.13*1.21 ± 0.121.43 ± 0.07
LV mass (mg)69 ± 585 ± 7*72 ± 974 ± 5
Normalized LV mass (mg/g)2.50 ± 0.212.62 ± 0.202.42 ± 0.242.40 ± 0.27
Fraction shortening (%)48.0 ± 2.637.2 ± 1.7*48.1 ± 3.547.7 ± 1.7
  • Data are means ± SEM. n = 15–16 mice per group. FVB-LF, FVB mice fed a low-fat diet; FVB-HF, mice fed a high-fat diet; MT-LF, metallothionein mice fed a low-fat diet; MT-HF, metallothionein mice fed a high-fat diet. LV, left ventricular.

  • *

    * P < 0.05 vs. FVB group.